Parvalbumin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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-[[Image:4cpv.png|left|200px|thumb|Crystal Structure of Parvalbumin [[4cpv]]]]
+<StructureSection load='' size='350' side='right' caption='Pike parvalbumin complex with Ca+2 ions (green), ammonium ion (blue), acetyl and formate (PDB entry [[2pvb]])' scene='46/466520/Cv/2' pspeed='8'>
-{{STRUCTURE_4cpv|  PDB=4cpv  | SIZE=300| SCENE=Parvalbumin/Cv/1 |right|CAPTION=Parvalbumin complex with acetate and Ca+2 ions [[4cpv]] }}
+== Function ==
+'''Parvalbumin (PVA)''' is a calcium-binding albumin protein.  PVA is involved in calcium signaling<ref>PMID:11867433</ref>.  PVA contains 3 domains each containing 2 helices: AB, CD (N-terminal) and EF (C-terminal). '''α-parvalbumin''' differs from '''β-parvalbumin''' in 54 positions.  α-parvalbumin is expressed in various tissues while β-parvalbumin is expressed only in preterm placenta<ref>PMID:8354278</ref>. <br />
+See also<br />
+* [[EF hand]]
+* [[Parvalbumin carp]].
-'''Parvalbumin (PVA)''' is a calcium-binding albumin protein.  PVA is involved in calcium signaling.  PVA contains 3 domains: AB, CD (N-terminal) and EF (C-terminal). The images at the left and at the right correspond to one representative PVA, ''i.e.'' the crystal structure of carp Parvalbumin ([[4cpv]]).
+== Relevance ==
+PVA is a major fish allergen<ref>PMID:18221468</ref>.
-{{TOC limit|limit=2}}
+== Structural highlights ==
-<br />
+PVA contains a <scene name='46/466520/Cv/10'>heptacoordinated Ca+2 ion binding to 7 oxygen atoms</scene> in a <scene name='46/466520/Cv/11'>typical EF-hand</scene> coordination<ref>PMID:10548066</ref>. Water molecules are shown as red spheres. <scene name='46/466520/Cv/12'>Calcium ion is coordinated by seven oxygen atoms that form a pentagonal bipyramid </scene>.
-<br />
+*<scene name='46/466520/Cv/13'>Ammonium ion coordination site</scene>.
-<br />
+</StructureSection>
-<br />
-<br />
 == 3D Structures of Parvalbumin ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[4cpv]], [[5cpv]] – cPVA - carp<br />
+*parvalbumin
-[[1cdp]] – cPVA Cd-substituted<br />
-[[1b8c]], [[1b8r]], [[1b9a]], [[1b8l]] – cPVA (mutant)<br />
-[[1pal]], [[2pal]], [[3pal]], [[4pal]], [[1pvb]], [[1pva]], [[2pvb]] – pPVA – pike<br />
-[[2pas]], [[3pat]] – pPVA – NMR<br />
-[[1a75]] – PVA – whiting
-===α-parvalbumin===
+**[[4cpv]], [[5cpv]] – cPVA - carp<br />
+**[[1cdp]] – cPVA Cd-substituted<br />
+**[[1b8c]], [[1b8r]], [[1b9a]], [[1b8l]] – cPVA (mutant)<br />
+**[[1pal]], [[2pal]], [[3pal]], [[4pal]], [[1pvb]], [[1pva]], [[2pvb]] – pPVA – pike<br />
+**[[2pas]], [[3pat]] – pPVA – NMR<br />
+**[[1a75]] – PVA – whiting<br />
+**[[1bu3]] – PVA Ca-binding domain – hake<br />
+**[[5zgm]] – MgPVA SPV-I – ''Mustelus griseus''<br />
+**[[5zh6]] – MgPVA SPV-II<br />
-[[5pal]] – PVA-α - shark<br />
+*α-parvalbumin
-[[1rtp]], [[1rwy]] - rPVA-α - rat<br />
-[[2jww]] - rPVA-α Ca-free – NMR<br />
-[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br />
-[[1rjv]], [[1rk9]] - hPVA-α - human – NMR
-===β-parvalbumin===
+**[[1rjv]], [[1rk9]] - hPVA-α - human – NMR<br />
+**[[1rtp]], [[1rwy]] - rPVA-α - rat<br />
+**[[2jww]] - rPVA-α Ca-free – NMR<br />
+**[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br />
+**[[5pal]] – PVA-α - shark<br />
-[[2nln]] - rPVA-β Ca-free – NMR<br />
+*β-parvalbumin (oncomodulin)
-[[1ttx]] - hPVA-β (mutant) – NMR<br />
-[[3fs7]] - chPVA-β - chicken<br />
-[[2kqy]] – chPVA-β – NMR<br />
-[[2kyc]] - chPVA-β <br />
-[[2kyf]] - chPVA-β (mutant) – NMR
+**[[1ttx]] - hPVA-β (mutant) – NMR<br />
+**[[2nln]] - rPVA-β Ca-free – NMR<br />
+**[[1rro]], [[1omd]] - rPVA-β  <br />
+**[[3fs7]] - chPVA-β - chicken<br />
+**[[2kqy]] – chPVA-β – NMR<br />
+**[[2kyc]] - chPVA-β <br />
+**[[2kyf]] - chPVA-β (mutant) – NMR<br />
+**[[2mbx]] - PVA-β – cod - NMR<br />
+**[[5xnd]] - PVA-β – mackerel - NMR<br />
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]