Myomesin: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='2y23' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Myomesin''' or '''Skelemin''' is expressed in striated muscle cell... |
Michal Harel (talk | contribs) No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='2y23' size='340' side='right' caption='Human myomesin-1 immunoglobulin-like domains 9-11 (PDB code [[2y23]])' scene=''> | |||
<StructureSection load='2y23' size='340' side='right' caption=' | |||
== Function == | == Function == | ||
'''Myomesin''' or '''Skelemin''' is expressed in striated muscle cells. It contains type-III fibronectin (motif I) and C2-immunoglobulin (motif II) domains<ref>PMID:18521710</ref>. Myomesin is found in the M-bridges of sarcomeres which produce the muscle contraction and provide their elasticity. The giant protein [[Titin]] interconnects the major structure of sarcomeres - the M bands and Z discs. The C-terminal of titin binds to myomesin-1 and myomesin-2. Myomesin-1 and myomesin-2 have a unique N-terminal region followed by 12 motifs in the order of II-II-I-I-I-I-I-II-II-II-II-II<ref>PMID:15890201</ref>. | '''Myomesin''' or '''Skelemin''' is expressed in striated muscle cells. It contains type-III fibronectin (motif I) and C2-immunoglobulin (motif II) domains<ref>PMID:18521710</ref>. Myomesin is found in the M-bridges of sarcomeres which produce the muscle contraction and provide their elasticity. The giant protein [[Titin]] interconnects the major structure of sarcomeres - the M bands and Z discs. The C-terminal of titin binds to myomesin-1 and myomesin-2. Myomesin-1 and myomesin-2 have a unique N-terminal region followed by 12 motifs in the order of<br /> II-II-I-I-I-I-I-II-II-II-II-II<ref>PMID:15890201</ref>. | ||
== | == Relevance == | ||
The up-regulation of myimesin denotes an adaptive remodeling of the sarcomere cytoskeleton in dilated heart and mya serve as a marker for dilated cardiomyopathy<ref>PMID:21069531</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The structure of myomesin-1 domains 9-11 show a superhelical coil arrangement which can be stretched to about 2.5-fold of its original length by reversible unfolding of the linkers. This property of the protein can explains its role in the elasticity of muscle fibers<ref>PMID:22347812</ref>. | |||
</StructureSection> | </StructureSection> | ||
| Line 20: | Line 20: | ||
[[5fm4]], [[5fm8]] - hMyo-1 domain 4 510-618 - human<br /> | [[5fm4]], [[5fm8]] - hMyo-1 domain 4 510-618 - human<br /> | ||
[[5fm5]] - hMyo-1 domains 4-5 | [[6zva]] - hMyo-1 domain 5 632-735 <br /> | ||
[[5fm5]] - hMyo-1 domains 4-5 + obscurin-like-1 <br /> | |||
[[2y23]] - hMyo-1 domains 9-11 1141-1447 <br /> | [[2y23]] - hMyo-1 domains 9-11 1141-1447 <br /> | ||
[[6t3o]] - hMyo-1 domain 10 1247-1357 <br /> | |||
[[2r15]] - hMyo-1 domains 12-13 1225-1443 <br /> | [[2r15]] - hMyo-1 domains 12-13 1225-1443 <br /> | ||
[[3rbs]] - hMyo-1 domains 10-11 1247-1447 <br /> | [[3rbs]] - hMyo-1 domains 10-11 1247-1447 <br /> | ||