Muconate cycloisomerase: Difference between revisions

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{{STRUCTURE_3fyy|  PDB=3fyy | SIZE=400| SCENE= |right|CAPTION=Muconate cycloisomerase dimer complex with Mg+2 ion, [[3fyy]] }}
<StructureSection load='3fyy' size='350' side='right' caption='Muconate cycloisomerase dimer complex with Mg+2 ion (green) (PDB entry [[3fyy]])' scene=''>


'''{{TOC limit|limit=2}}
'''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from ''cis,cis''-muconate.  It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds<ref>PMID:9726873</ref>.  MCI breaks down lignin-derived catechol and protocatechuate.


'''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from cis, cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds.
*'''Chloromuconate cycloisomerase''' catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to ''cis,cis''-butadiene-1,2,4-tricarboxylate <ref>PMID:7305906</ref>.<br />
*'''3-carboxy-''cis,cis''-muconate cycloisomerase''' catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-chloro-''cis,cis''-muconate<ref>PMID:5916392</ref>.<br />


{{TOC limit|limit=2}}
</StructureSection>


== 3D Structures of muconate cycloisomerase ==
== 3D Structures of muconate cycloisomerase ==


===Cloro-MCI===
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


[[2chr]] – MCI – ''Cupriavidsua  necator''<br />
*'''Chloro-MCI'''
[[1nus]] - MCI – ''Pseudomonas''


===cis, cis-MCI===
**[[2chr]] – MCI – ''Cupriavidsua  necator''<br />
**[[1nu5]] - MCI – ''Pseudomonas''<br />
**[[4m0x]] – MCI – ''Rhodococcus opacus''<br />


[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br />
*'''MCI'''
[[3muc]], [[2muc]], [[1f9c]] – PbMCI (mutant) <br />
[[1oqy]], [[3fyy]] – OiMCI – ''Oceanobacillus iheyensis''<br />
[[3i4k]] – MCI – ''Corynebacterium glutamicum''<br />
[[3i6e]] – MCI – ''Ruegeria pomeroyi''<br />
[[3i6t]] – MCI – ''Jannaschia''<br />
[[3my9]] – MCI – ''Azorhizobium caulinodans''<br />
[[2zad]] – TmMCI – ''Thermotoga maritima''<br />
[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br />
[[3dg3]] – MsMCI - ''Mycobacterium smegmatis''


===cis, cis-MCI complexes===
**[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br />
**[[3muc]], [[2muc]], [[1f9c]] – PbMCI (mutant) <br />
**[[2oqy]], [[3fyy]] – OiMCI – ''Oceanobacillus iheyensis''<br />
**[[3i4k]] – MCI – ''Corynebacterium glutamicum''<br />
**[[3i6e]] – MCI – ''Ruegeria pomeroyi''<br />
**[[3i6t]] – MCI – ''Jannaschia''<br />
**[[3my9]] – MCI – ''Azorhizobium caulinodans''<br />
**[[2zad]] – TmMCI – ''Thermotoga maritima''<br />
**[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br />
**[[3dg3]] – MsMCI - ''Mycobacterium smegmatis''<br />
**[[3fcp]] – MCI – ''Klebsiella pneumoniae''<br />


[[3es7]], [[3es8]] – OiMCI + Mg + malate<br />
*MCI complexes
[[3gd6]] – OiMCI + phosphate<br />
[[3hpf]] – OiMCI (mutant) + Mg + galactarate<br />
[[3dg6]], [[3dg7]] – MsMCI + muconolactone<br />
[[3dgb]], [[3fj4]] - PfMCI + muconolactone


===3-carboxy-cis, cis-MCI===
**[[3es7]], [[3es8]] – OiMCI + Mg + malate<br />
**[[3gd6]] – OiMCI + phosphate<br />
**[[3hpf]] – OiMCI (mutant) + Mg + galactarate<br />
**[[3dg6]], [[3dg7]] – MsMCI + muconolactone<br />
**[[3dgb]], [[3fj4]] - PfMCI + muconolactone


[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br />
*'''3-carboxy-cis, cis-MCI'''
[[1re5]] - PbMCI


===Dipeptide epimerase===
**[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br />
**[[1re5]] - PbMCI <br />
**[[1jof]] – MCI – ''Neurospora crassa''<br />
**[[2fel]], [[2fen]] – MCI – ''Agrobacterium tumefaciens''<br />


[[3iji]], [[3ijl]], [[3ijq]]– MCI + dipeptide – ''Bacterioides thetaiotaomicron''<br />
*'''Dipeptide epimerase'''
[[3deq]], [[3der]], [[3des]] – TmMCI + dipeptide<br />
[[3dfy]] – TmMCI<br />
[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br />
[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus''


**[[3iji]], [[3ijl]], [[3ijq]]– MCI + dipeptide – ''Bacterioides thetaiotaomicron''<br />
**[[3deq]], [[3der]], [[3des]] – TmMCI + dipeptide<br />
**[[3dfy]] – TmMCI<br />
**[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br />
**[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus''<br />
**[[3jva]] – EfMCI + Mg – ''Enterococcus faecalis''<br />
**[[3jw7]], [[3jzu]], [[3k1g]], [[3kum]] – EfMCI + Mg + dipeptide<br />
}}
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 13:31, 10 November 2021


Muconate cycloisomerase (MCI) catalyzes the formation of muconolactone from cis,cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds[1]. MCI breaks down lignin-derived catechol and protocatechuate.

  • Chloromuconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to cis,cis-butadiene-1,2,4-tricarboxylate [2].
  • 3-carboxy-cis,cis-muconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-chloro-cis,cis-muconate[3].


Muconate cycloisomerase dimer complex with Mg+2 ion (green) (PDB entry 3fyy)

Drag the structure with the mouse to rotate

3D Structures of muconate cycloisomerase3D Structures of muconate cycloisomerase

Updated on 10-November-2021

ReferencesReferences

  1. ↑ Vollmer MD, Hoier H, Hecht HJ, Schell U, Groning J, Goldman A, Schlomann M. Substrate specificity of and product formation by muconate cycloisomerases: an analysis of wild-type enzymes and engineered variants. Appl Environ Microbiol. 1998 Sep;64(9):3290-9. PMID:9726873
  2. ↑ Schmidt E, Knackmuss HJ. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem J. 1980 Oct 15;192(1):339-47. PMID:7305906
  3. ↑ Ornston LN. The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. II. Enzymes of the protocatechuate pathway. J Biol Chem. 1966 Aug 25;241(16):3787-94. PMID:5916392

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