2wed: Difference between revisions

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-[[Image:2wed.jpg|left|200px]]<br /><applet load="2wed" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2wed, resolution 1.5&Aring;" />
-'''ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE MACROCYCLIC INHIBITOR:METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE], SODIUM SALT'''<br />
-==About this Structure==
+==ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE MACROCYCLIC INHIBITOR:METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE], SODIUM SALT==
-WED is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum] with <scene name='pdbligand=MAN:'>MAN</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=PP6:'>PP6</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1WED. Active as [http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] Known structural/functional Site: <scene name='pdbsite=CIC:Catalytic+Site'>CIC</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WED OCA].
+<StructureSection load='2wed' size='340' side='right'caption='[[2wed]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2wed]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wed 1wed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WED FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PP6:METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYLOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE]'>PP6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wed OCA], [https://pdbe.org/2wed PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wed RCSB], [https://www.ebi.ac.uk/pdbsum/2wed PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wed ProSAT]</span></td></tr>
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wed_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wed ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Penicillopepsin|Penicillopepsin]]
+*[[Pepsin|Pepsin]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Penicillium janthinellum]]
 [[Category: Penicillopepsin]]
-[[Category: Single protein]]
+[[Category: Ding, J]]
-[[Category: Ding, J.]]
+[[Category: Fraser, M E]]
-[[Category: Fraser, M E.]]
+[[Category: James, M N.G]]
-[[Category: James, M N.G.]]
+[[Category: Hydrolase]]
-[[Category: MAN]]
+[[Category: Macrocyclic inhibitor]]
-[[Category: PP6]]
-[[Category: SO4]]
-[[Category: hydrolase]]
-[[Category: macrocyclic inhibitor]]
-[[Category: penicillopepsin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:56:58 2008''