2rel: Difference between revisions

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-[[Image:2rel.png|left|200px]]
-{{STRUCTURE_2rel|  PDB=2rel  |  SCENE=  }}
+==SOLUTION STRUCTURE OF R-ELAFIN, A SPECIFIC INHIBITOR OF ELASTASE, NMR, 11 STRUCTURES==
+<StructureSection load='2rel' size='340' side='right'caption='[[2rel]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2rel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rel 1rel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REL FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rel OCA], [https://pdbe.org/2rel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rel RCSB], [https://www.ebi.ac.uk/pdbsum/2rel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rel ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/ELAF_HUMAN ELAF_HUMAN]] Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2rel_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rel ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The solution structure of r-elafin, a specific elastase inhibitor, has been determined using NMR spectroscopy. Characterized by a flat core and a flexible N-terminal extremity, the three-dimensional structure is formed by a central twisted beta-hairpin accompanied by two external segments linked by the proteinase binding loop. A cluster of three disulfide bridges connects the external segments to the central beta-sheet and a single fourth disulfide bridge links the binding loop to the central beta-turn. The same spatial distribution of disulfide bridges can be observed in both domains of the secretory leukocyte protease inhibitor (SLPI), another elastase inhibitor. The structural homology between r-elafin and the C-terminal domain of SLPI confirms the former as a second member of the chelonianin family of proteinase inhibitors. Based on the homology between the two proteins and recent results obtained for elastase binding mutants of the bovine pancreatic trypsin inhibitor (BPTI), we define the segment 22 to 27 as the binding loop of elafin, with the scissile peptide bond between Ala24 and Met25. In our solution structures, this loop is extended and solvent-exposed, and exhibits a large degree of flexibility. This mobility, already observed for the binding loop in other protease inhibitors in solution, might be an important feature for the interaction with the corresponding protease.
-===SOLUTION STRUCTURE OF R-ELAFIN, A SPECIFIC INHIBITOR OF ELASTASE, NMR, 11 STRUCTURES===
+Solution structure of R-elafin, a specific inhibitor of elastase.,Francart C, Dauchez M, Alix AJ, Lippens G J Mol Biol. 1997 May 9;268(3):666-77. PMID:9171290<ref>PMID:9171290</ref>
-{{ABSTRACT_PUBMED_9171290}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2rel" style="background-color:#fffaf0;"></div>
-[[2rel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rel 1rel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REL OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:009171290</ref><references group="xtra"/>
+</StructureSection>
-[[Category: Homo sapiens]]
+[[Category: Human]]
-[[Category: Alix, A J.P.]]
+[[Category: Large Structures]]
-[[Category: Dauchez, M.]]
+[[Category: Alix, A J.P]]
-[[Category: Francart, C.]]
+[[Category: Dauchez, M]]
-[[Category: Lippens, G.]]
+[[Category: Francart, C]]
+[[Category: Lippens, G]]
 [[Category: Elastase inhibitor]]
 [[Category: R-elafin]]
 [[Category: Serine protease inhibitor]]