3ft4: Difference between revisions

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-{{Seed}}
-[[Image:3ft4.jpg|left|200px]]
-<!--
+==Crystal Structure of the minor histocompatibility peptide HA-1Arg in complex with HLA-A2==
-The line below this paragraph, containing "STRUCTURE_3ft4", creates the "Structure Box" on the page.
+<StructureSection load='3ft4' size='340' side='right'caption='[[3ft4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ft4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FT4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P, HLA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ft4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ft4 OCA], [https://pdbe.org/3ft4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ft4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ft4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ft4 ProSAT]</span></td></tr>
-{{STRUCTURE_3ft4|  PDB=3ft4  |  SCENE=  }}
+</table>
+== Disease ==
+[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[https://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/3ft4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ft4 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The di-allelic HLA-A2 restricted minor histocompatibility Ag HA-1 locus codes for the highly immunogenic HA-1(His) and the nonimmunogenic HA-1(Arg) nonapeptides, differing in one amino acid. The HA-1(His) peptide is currently used for boosting the graft-vs-tumor responses after HLA matched HA-1 mismatched stem cell transplantation; usage of the HA-1(Arg) peptide would significantly enlarge the applicability for this therapy. Our studies on mechanisms causing the HA-1 unidirectional immunogenicity revealed marginal differences in proteasomal digestion, TAP translocation, and binding affinity, whereas both dissociation rates and structural analyses clearly showed marked differences in the stability of these two HLA-A2 bound alleles. These data provide a rationale for the lack of HA-1(Arg) peptide immunogenicity essential for the choice of tumor peptides for stem cell-based immunotherapeutic application.
-===Crystal Structure of the minor histocompatibility peptide HA-1Arg in complex with HLA-A2===
+Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.,Spierings E, Gras S, Reiser JB, Mommaas B, Almekinders M, Kester MG, Chouquet A, Le Gorrec M, Drijfhout JW, Ossendorp F, Housset D, Goulmy E J Immunol. 2009 Apr 15;182(8):4809-16. PMID:19342659<ref>PMID:19342659</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3ft4" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_19342659}}, adds the Publication Abstract to the page
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 19342659 is the PubMed ID number.
+*[[MHC 3D structures|MHC 3D structures]]
--->
+== References ==
-{{ABSTRACT_PUBMED_19342659}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-FT4 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FT4 OCA].
+[[Category: Human]]
+[[Category: Large Structures]]
-==Reference==
+[[Category: Chouquet, A]]
-<ref group="xtra">PMID:19342659</ref><references group="xtra"/>
+[[Category: Gorrec, M Le]]
-[[Category: Homo sapiens]]
+[[Category: Goulmy, E]]
-[[Category: Chouquet, A.]]
+[[Category: Gras, S]]
-[[Category: Gorrec, M Le.]]
+[[Category: Housset, D]]
-[[Category: Goulmy, E.]]
+[[Category: Reiser, J B]]
-[[Category: Gras, S.]]
+[[Category: Spierings, E]]
-[[Category: Housset, D.]]
-[[Category: Reiser, J B.]]
-[[Category: Spierings, E.]]
 [[Category: Antigen presentation]]
 [[Category: Antigen processing]]
@@ Line 40: / Line 55: @@
 [[Category: Human minor h antigen]]
 [[Category: Immune response]]
+[[Category: Immune system]]
 [[Category: Immunogenicity]]
 [[Category: Immunoglobulin domain]]
@@ Line 46: / Line 62: @@
 [[Category: Polymorphism]]
 [[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 10:02:08 2009''