Leucine transporter: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='450' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1' pspeed='8'> | ||
== Function == | == Function == | ||
'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. | '''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. <scene name='56/564069/Cv/5'>The LeuT is a homodimer</scene><ref>PMID:15980244</ref>. | ||
==Relevance == | ==Relevance == | ||
LeuT is the target of many antidepressant and recreational drugs. | LeuT is the target of many antidepressant and recreational drugs. | ||
== Structural highlights == | |||
*<scene name='56/564069/Cv/6'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>. | |||
*The <scene name='56/564069/Cv/7'>leucine binding pocket of LeuT contains 2 Na+ ions</scene><ref>PMID:22245965</ref>. | |||
*<scene name='56/564069/Cv/8'>Leucine binding pocket</scene>. | |||
==3D structures of leucine transporter== | ==3D structures of leucine transporter== | ||
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[[3mpn]], [[3mpq]] – AaLeuT (mutant) + Leu + Na + halide<br /> | [[3mpn]], [[3mpq]] – AaLeuT (mutant) + Leu + Na + halide<br /> | ||
[[3f3e]], [[3usg]], [[3usj]], [[3usi]], [[3usk]] – AaLeuT + Leu + Na <br /> | [[3f3e]], [[3usg]], [[3usj]], [[3usi]], [[3usk]] – AaLeuT + Leu + Na <br /> | ||
[[4fxz]], [[3gjc]] – AaLeuT (mutant) + Leu + Na <br /> | [[4fxz]], [[3gjc]], [[6nle]] – AaLeuT (mutant) + Leu + Na <br /> | ||
[[3f48]], [[3f4j]], [[3f3a]], [[3f3c]], [[3f3d]], [[3f4i]] – AaLeuT + amino acid + Na <br /> | [[3f48]], [[3f4j]], [[3f3a]], [[3f3c]], [[3f3d]], [[3f4i]], [[6xwm]] – AaLeuT + amino acid + Na <br /> | ||
[[3qs4]], [[3qs5]], [[3qs6]], [[4fy0]], [[3tu0]], [[3usl]], [[3uso]], [[3usm]] – AaLeuT (mutant) + amino acid + Na <br /> | [[3qs4]], [[3qs5]], [[3qs6]], [[4fy0]], [[3tu0]], [[3usl]], [[3uso]], [[3usm]], [[7lqj]], [[7lqk]], [[7lql]] – AaLeuT (mutant) + amino acid + Na <br /> | ||
[[3tt1]] – AaLeuT (mutant) + Na + antibody<br /> | [[3tt1]] – AaLeuT (mutant) + Na + antibody<br /> | ||
[[3tt3]] – AaLeuT (mutant) + antibody<br /> | [[3tt3]] – AaLeuT (mutant) + antibody<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||