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| {{STRUCTURE_3mfr| PDB=3mfr | SIZE=400| SCENE=CaMKc/Cv/1 |right|CAPTION=Ca2+/Calmodulin dependent protein kinase CASK complex with phosphoaminophosphonic acid-adenylate ester, [[3mfr]] }}
| | <StructureSection load='2vz6' size='350' side='right' scene='41/415817/Cv/2' caption='Human CamKII subunit α kinase domain complex with indirubin (PDB code [[2vz6]])'> |
| __TOC__ | | __TOC__ |
| == Function == | | == Function == |
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| [[Ca2+/Calmodulin dependent protein kinase]] (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. <br />
| | Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. <br /> |
| *'''CaMKI''' is a specialized CaM kinase.<br /> | | *'''CaMKI''' is a specialized CaM kinase.<br /> |
| *'''CaMKII''' is multifunctional kinase. <br /> | | *'''CaMKII''' is multifunctional kinase. <br /> |
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| == Structural highlights == | | == Structural highlights == |
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| CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. | | CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref> |
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| == 3D Structures of Ca<sup>2+</sup>/Calmodulin dependent protein kinase == | | == 3D Structures of Calcium/calmodulin dependent protein kinase == |
| | [[Calcium/calmodulin dependent protein kinase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * CaMKI – specialized CaM kinase
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| **[[1a06]] – rCaMK - rat<br />
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| **[[3nyv]], [[3n51]], [[3i7b]], [[3i7c]], [[3hzt]] – TgCaMK + inhibitor – ''Toxoplasma gondii''<br />
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| **[[3ku2]], [[3i79]] - TgCaMK <br />
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| **[[3khe]] – TgCaMK residues 345-535 + Ca<br />
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| **[[3hx4]] – TgCaMK+Ca<br />
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| **[[3dxn]], [[3is5]] – TgCaMK kinase domain + Ca<br />
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| **[[3mwu]] – CpCaMK (mutant)+ inhibitor + Ca – ''Cryptosporidium parvum''<br />
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| **[[3ncg]] - CpCaMK + inhibitor + Ca <br />
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| **[[3igo]] - CpCaMK +Ca <br />
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| **[[3hko]] - CpCaMK kinase domain residues 125-452 + Zn<br />
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| **[[2qg5]], [[3dfa]] – CpCaMK kinase domain<br />
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| **[[3f3z]] – CpCaMK kinase domain+indirubin_E804<br />
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| **[[2aao]] – CaMK C terminal + Ca – ''Arabidopsis thaliana''<br />
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| **[[1s6j]], [[1s6i]] – sCaMK α residues 329-402 + Ca – soybean - NMR<br />
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| * CASK – membrane-associated CaMK
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| **[[3mfr]] – hCASK CBD – human<br />
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| **[[3mfs]] – hCASK+AMPPNP<br />
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| **[[3mft]] – hCASK+Mn<br />
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| **[[3c0g]] – hCASK kinase domain<br />
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| **[[3c0h]] - hCASK kinase domain+AMPPNP<br />
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| **[[3c0i]] - hCASK kinase domain+AMP<br />
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| **[[3mfu]] - hCASK+AMPPNP+Mn<br />
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| * DAPK – death-associated CaMK
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| **[[2x0g]] – hDAPK RD+AD+CaM<br />
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| **[[2cke]] – hDAPK+inhibitor<br />
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| * CaMKII – multifunctional CaM kinase
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| **[[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br />
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| **[[2zv2]] – hCaMKII+STO-609<br />
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| **[[2wel]] - hCaMKII δ chain D+CaM<br />
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| **[[2w2c]] - hCaMKII δ chain ASD<br />
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| **[[2vn9]] - hCaMKII δ chains A-B<br />
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| **[[3bhh]] - hCaMKII β chains A-D<br />
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| **[[2v7o]] - hCaMKII γ chain A<br />
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| **[[2ux0]] - hCaMKII γ (mutant) chains A-F<br />
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| **[[2jam]] - hCaMKI γ+peptides<br />
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| **[[2jc6]] - hCaMKII δ chains A,C<br />
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| **[[1hkx]] - mCaMKII α chains A-N ASD - mouse<br />
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| **[[3gp2]] – cCaMKII δ chain B+CaM – chicken<br />
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| **[[3kk8]], [[3kk9]] – CeCaMKII – ''Caenorhabditis elegans''<br />
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| **[[3kl8]] – CeCaMKII (mutant)+inhibitor<br />
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| **[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br />
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| **[[3pm8]] – PfCaMKII CBD + Ca – ''Plasmodium falciparum'' <br />
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| **[[4mvf]] – PfCaMKII + Ca + staurosporine <br />
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| *CaMKIII
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| **[[3lij]] – CpCaMKIII +Ca<br />
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| **[[3l19]], [[3hko]] – CpCaMKIII CBD + Ca<br />
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| **[[3k21]] – PfCaMKIII C terminal + Ca <br />
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| **[[3jwq]] – CaMKIII C terminal + Ca – ''Plasmodium berhei'' <br />
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| **[[3o4y]] – CaMKIII C terminal + Ca – ''Plasmodium vivax'' <br />
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| * CaMKIV
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| **[[2w4o]] – hCaMKIV+inhibitor<br />
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| **[[4rgj]] – PfCaMKIV <br />
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| **[[4qox]] – PfCaMKIV + Mg <br />
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| }}
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
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| ==See also== | | ==References== |
| | | <references/> |
| [[Calcium-dependent protein kinase]], a member of the CaM kinase family | | See [[Calcium-dependent protein kinase]] |