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Calcium/Calmodulin-dependent protein kinase: Difference between revisions

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{{STRUCTURE_3mfr|  PDB=3mfr  | SIZE=400| SCENE=CaMKc/Cv/1 |right|CAPTION=Ca2+/Calmodulin dependent protein kinase complex with phosphoaminophosphonic acid-adenylate ester, [[3mfr]] }}
<StructureSection load='2vz6' size='350' side='right' scene='41/415817/Cv/2' caption='Human CamKII subunit α kinase domain complex with indirubin (PDB code [[2vz6]])'>
__TOC__
__TOC__
== Function ==
== Function ==


[[Ca2+/Calmodulin dependent protein kinase]] (CaMK) phosphorylates Ser and Thr.  <br />
Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr.  <br />
*'''CaMKI''' is a specialized CaM kinase.<br />
*'''CaMKI''' is a specialized CaM kinase.<br />
*'''CaMKII''' is multifunctional kinase. <br />
*'''CaMKII''' is multifunctional kinase. <br />
*'''CaMKIII''' phosphorylates eukaryotic elongation factor 2. <br />
*'''CASK''' is a membrane associated CaMK.<br />
*'''CASK''' is a membrane associated CaMK.<br />
*'''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death.   
*'''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death.  <br />
For details see [[Calcium-dependent protein kinase]].


== Structural highlights ==
== Structural highlights ==


CAMK contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD).  DAPK contains a regulatory (RD) and autoinhibitory (AD) domains.  
CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD).  DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref>


== 3D Structures of Ca<sup>2+</sup>/Calmodulin dependent protein kinase ==
== 3D Structures of Calcium/calmodulin dependent protein kinase ==
[[Calcium/calmodulin dependent protein kinase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|


* CaMKK – CaM kinase kinase
**[[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br />
* CaMKI – specialized CaM kinase
**[[1mxe]] – rCaMKI CBD+CaM – rat<br />
**[[1ckk]] – rCaMK CBD chain B+XlCaM<br />
**[[1a06]] – rCaMK chain A<br />
* CASK – membrane-associated CaMK
**[[3mfr]] – hCASK CBD – human<br />
**[[3mfs]] – hCASK+AMPPNP<br />
**[[3mft]] – hCASK+Mn<br />
**[[3c0g]] – hCASK kinase domain<br />
**[[3c0h]] - hCASK kinase domain+AMPPNP<br />
**[[3c0i]] - hCASK kinase domain+AMP<br />
**[[3mfu]] - hCASK+AMPPNP+Mn<br />
* DAPK – death-associated CaMK
**[[2x0g]] – hDAPK RD+AD+CaM<br />
**[[2cke]] – hDAPK+inhibitor<br />
* CaMKII – multifunctional CaM kinase
**[[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br />
**[[2zv2]] – hCaMKII+STO-609<br />
**[[2wel]] - hCaMKII δ chain D+CaM<br />
**[[2w2c]] - hCaMKII δ chain ASD<br />
**[[2vn9]] - hCaMKII δ chains A-B<br />
**[[3bhh]] - hCaMKII β chains A-D<br />
**[[2v7o]] - hCaMKII γ chain A<br />
**[[2ux0]] - hCaMKII γ (mutant) chains A-F<br />
**[[2jam]] - hCaMKI γ+peptides<br />
**[[2jc6]] - hCaMKII δ chains A,C<br />
**[[1hkx]] - mCaMKII α chains A-N ASD - mouse<br />
**[[3gp2]] – cCaMKII δ chain B+CaM – chicken<br />
**[[3kk8]], [[3kk9]] – CeCaMKII – ''Caenorhabditis elegans''<br />
**[[3kl8]] – CeCaMKII (mutant)+inhibitor<br />
**[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br />
* CaMKIV
**[[2w4o]] – hCaMKIV+inhibitor<br />
}}
[[Category:Topic Page]]
[[Category:Topic Page]]


==See also==
==References==
 
<references/>
[[Calcium-dependent protein kinase]], a member of the CaM kinase family
See [[Calcium-dependent protein kinase]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Alice Harmon, Jaime Prilusky
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