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| {{STRUCTURE_3mfr| PDB=3mfr | SIZE=400| SCENE=CaMKc/Cv/1 |right|CAPTION=Ca2+/Calmodulin dependent protein kinase complex with phosphoaminophosphonic acid-adenylate ester, [[3mfr]] }}
| | <StructureSection load='2vz6' size='350' side='right' scene='41/415817/Cv/2' caption='Human CamKII subunit α kinase domain complex with indirubin (PDB code [[2vz6]])'> |
| | __TOC__ |
| | == Function == |
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| [[Ca2+/Calmodulin dependent protein kinase]] (CaMK) phosphorylates Ser and Thr. It is regulated by Ca<sup>2+</sup>/[[Calmodulin]] (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. '''CASK''' is a membrane associated CaMK. '''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, ''i.e.'' crystal structure of human native membrane associated Ca<sup>2+</sup>/Calmodulin dependent protein kinase ([[3mfr]]).
| | Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. <br /> |
| | *'''CaMKI''' is a specialized CaM kinase.<br /> |
| | *'''CaMKII''' is multifunctional kinase. <br /> |
| | *'''CaMKIII''' phosphorylates eukaryotic elongation factor 2. <br /> |
| | *'''CASK''' is a membrane associated CaMK.<br /> |
| | *'''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death. <br /> |
| | For details see [[Calcium-dependent protein kinase]]. |
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| == 3D Structures of Ca<sup>2+</sup>/Calmodulin dependent protein kinase == | | == Structural highlights == |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * CaMKK – CaM kinase kinase
| | == 3D Structures of Calcium/calmodulin dependent protein kinase == |
| | [[Calcium/calmodulin dependent protein kinase 3D structures]] |
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| **[[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br />
| | </StructureSection> |
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| * CaMKI – specialized CaM kinase
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| **[[1mxe]] – rCaMKI CBD+CaM – rat<br />
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| **[[1ckk]] – rCaMK CBD chain B+XlCaM<br />
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| **[[1a06]] – rCaMK chain A<br />
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| * CASK – membrane-associated CaMK
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| **[[3mfr]] – hCASK CBD – human<br />
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| **[[3mfs]] – hCASK+AMPPNP<br />
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| **[[3mft]] – hCASK+Mn<br />
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| **[[3c0g]] – hCASK kinase domain<br />
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| **[[3c0h]] - hCASK kinase domain+AMPPNP<br />
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| **[[3c0i]] - hCASK kinase domain+AMP<br />
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| **[[3mfu]] - hCASK+AMPPNP+Mn<br />
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| * DAPK – death-associated CaMK
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| **[[2x0g]] – hDAPK RD+AD+CaM<br />
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| **[[2cke]] – hDAPK+inhibitor<br />
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| * CaMKII – multifunctional CaM kinase
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| **[[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br />
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| **[[2zv2]] – hCaMKII+STO-609<br />
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| **[[2wel]] - hCaMKII δ chain D+CaM<br />
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| **[[2w2c]] - hCaMKII δ chain ASD<br />
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| **[[2vn9]] - hCaMKII δ chains A-B<br />
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| **[[3bhh]] - hCaMKII β chains A-D<br />
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| **[[2v7o]] - hCaMKII γ chain A<br />
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| **[[2ux0]] - hCaMKII γ (mutant) chains A-F<br />
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| **[[2jam]] - hCaMKI γ+peptides<br />
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| **[[2jc6]] - hCaMKII δ chains A,C<br />
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| **[[1hkx]] - mCaMKII α chains A-N ASD - mouse<br />
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| **[[3gp2]] – cCaMKII δ chain B+CaM – chicken<br />
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| **[[3kk8]], [[3kk9]] – CeCaMKII – ''Caenorhabditis elegans''<br />
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| **[[3kl8]] – CeCaMKII (mutant)+inhibitor<br />
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| **[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br />
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| * CaMKIV
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| **[[2w4o]] – hCaMKIV+inhibitor<br />
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| }}
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
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| ==See also== | | ==References== |
| | | <references/> |
| [[Calcium-dependent protein kinase]], a member of the CaM kinase family | | See [[Calcium-dependent protein kinase]] |