Calcium/Calmodulin-dependent protein kinase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Alice Harmon, Jaime Prilusky

@@ Line 1: / Line 1: @@
-[[Image:3mfr.png|left|200px|thumb|Crystal Structure of membrane associated Ca2+/Calmodulin dependent protein kinase, [[3mfr]]]]
+<StructureSection load='2vz6' size='350' side='right' scene='41/415817/Cv/2' caption='Human CamKII subunit α kinase domain complex with indirubin (PDB code [[2vz6]])'>
-{{STRUCTURE_3mfr|  PDB=3mfr  | SIZE=300| SCENE= |right|CAPTION=Ca2+/Calmodulin dependent protein kinase, [[3mfr]] }}
+__TOC__
+== Function ==
+Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr.  <br />
+*'''CaMKI''' is a specialized CaM kinase.<br />
+*'''CaMKII''' is multifunctional kinase. <br />
+*'''CaMKIII''' phosphorylates eukaryotic elongation factor 2. <br />
+*'''CASK''' is a membrane associated CaMK.<br />
+*'''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death.   <br />
+For details see [[Calcium-dependent protein kinase]].
+== Structural highlights ==
+CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD).  DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref>
+== 3D Structures of Calcium/calmodulin dependent protein kinase ==
+[[Calcium/calmodulin dependent protein kinase 3D structures]]
+</StructureSection>
+[[Category:Topic Page]]
+==References==
+<references/>
+See [[Calcium-dependent protein kinase]]