1ks1: Difference between revisions

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 {{Theoretical_model}}
-[[Image:1ks1.png|left|200px]]
+==A MODEL FOR A FIVE-PRIME STACKED TRNA==
+<StructureSection load='1ks1' size='340' side='right'caption='[[1ks1]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KS1 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ks1 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1ks1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ks1 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+During decoding, a codon of messenger RNA is matched with its cognate aminoacyl-transfer RNA and the amino acid carried by the tRNA is added to the growing protein chain. Here we propose a molecular mechanism for the decoding phase of translation: the transorientation hypothesis. The model incorporates a newly identified tRNA binding site and utilizes a flip between two tRNA anticodon loop structures, the 5'-stacked and the 3'-stacked conformations. The anticodon loop acts as a three-dimensional hinge permitting rotation of the tRNA about a relatively fixed codon-anticodon pair. This rotation, driven by a conformational change in elongation factor Tu involving GTP hydrolysis, transorients the incoming tRNA into the A site from the D site of initial binding and decoding, where it can be proofread and accommodated. The proposed mechanisms are compatible with the known structures, conformations and functions of the ribosome and its component parts including tRNAs and EF-Tu, in both the GTP and GDP states.
-{{STRUCTURE_1ks1|  PDB=1ks1  |  SCENE=  }}
+The transorientation hypothesis for codon recognition during protein synthesis.,Simonson AB, Lake JA Nature. 2002 Mar 21;416(6878):281-5. PMID:11907568<ref>PMID:11907568</ref>
-===A MODEL FOR A FIVE-PRIME STACKED TRNA===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_11907568}}
+<div class="pdbe-citations 1ks1" style="background-color:#fffaf0;"></div>
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:011907568</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Theoretical Model]]
+[[Category: Large Structures]]
 [[Category: Lake, J A]]
 [[Category: Simonson, A B]]