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| == Function == | | == Function == |
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| The virus contains a surface '''glycoprotein PG''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>. Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion. | | The virus contains a surface '''glycoprotein GP''' or '''envelope glycoprotein GP''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>. Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion. |
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| For details see [[GP1 of Lassa Virus]]. | | For details see [[GP1 of Lassa Virus]]. |
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| </StructureSection> | | </StructureSection> |
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| == 3D Structures of glycoprotein GP ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Glycoprotein GP
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| **[[2wfo]] – MvGP1 – Machupo virus <br />
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| **[[4zjf]] – GP1 – Lassa virus <br />
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| **[[5nff]] – GP1 – Morogoro virus <br />
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| **[[5nsj]] – GP1 – Whitewater arroyo mammarenavirus <br />
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| **[[3lj5]], [[4v4k]] – GP1 – Bacteriophage p22 <br />
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| **[[4n21]], [[4n23]] – GP2 ectodomain – CAS virus <br />
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| **[[5jq3]] – ZevGP1 + GP2 – Zaire ebolavirus <br />
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| *Glycoprotein GP complex
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| **[[3ve0]], [[3s88]] – GP1 + GP2 + antibody – Sudan ebolavirus <br />
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| **[[5f1b]] – ZevGP1 + GP2 + Niemann-Pick C1 protein <br />
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| **[[5jnx]] – ZevGP1 (mutant) + GP2 + Niemann-Pick C1 protein – Cryo EM<br />
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| **[[6f5u]], [[6f6i]], [[6f6n]], [[6f6s]] – ZevGP1 + GP2 + antidepressant <br />
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| **[[5jqb]] – ZevGP1 + GP2 + ibuprofen<br />
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| **[[5jq7]] – ZevGP1 + GP2 + toremifene<br />
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| **[[6g9i]], [[6g9b]], [[6g95]] – ZevGP1 (mutant) + GP2 (mutant) + antidepressant <br />
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| **[[6hs4]], [[6hro]] – ZevGP1 (mutant) + GP2 (mutant) + inhibitor <br />
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| **[[3csy]], [6mam]], [[6eay]], [[6ea7]], [[5hj3]], [[5hfc]] – ZevGP1 + GP2 + antibody <br />
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| **[[5kel]], [[5ken]], [[6dzl]] – ZevGP1 + GP2 + antibody - Cryo EM<br />
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| **[[6dzm]] – GP1 + GP2 + antibody – Bundibugyo ebolavirus - Cryo EM<br />
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| **[[5uqy]], [[6bp2]] – GP1 + GP2 + antibody – Marburg virus <br />
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| **[[3kas]] – MvGP1 + transferrin receptor 1 <br />
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| **[[5nuz]] – GP1 + antibody – Junin virus <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |