1k11: Difference between revisions

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 {{Theoretical_model}}
-{{Seed}}
-[[Image:1k11.png|left|200px]]
-<!--
+==THEORETICAL STRUCTURE OF ICAP1-ALPHA BOUND TO INTEGRIN BETA1 CYTOPLASMIC DOMAIN==
-The line below this paragraph, containing "STRUCTURE_1k11", creates the "Structure Box" on the page.
+<StructureSection load='1k11' size='340' side='right'caption='[[1k11]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K11 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k11 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1k11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k11 ProSAT]</span></td></tr>
--->
+</table>
-{{STRUCTURE_1k11|  PDB=1k11  |  SCENE=  }}
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Icap1 alpha is a 200-amino acid protein that binds to the COOH-terminal 13 amino acids ((786)AVTTVVNPKYEGK(798)) of the integrin beta(1) subunit. Alanine scanning mutagenesis of this region revealed that Val(787), Val(790), and (792)NPKY(795) are critical for Icap1 alpha binding. The NPXY motif is a known binding substrate for phosphotyrosine binding (PTB) domain proteins. The sequences of Icap1 alpha, residues 58--200, and the beta(1) integrin, residues 786-797, were aligned to the available PTB-peptide structures to generate a high quality structural model. Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, residues predicted by the model to be in close proximity to (792)NPKY(795), and Leu(82) and Tyr(144), residues expected to form a hydrophobic pocket near Val(787), are required for the Icap1 alpha-beta(1) integrin interaction. These findings indicate that Icap1 alpha is a PTB domain protein, which recognizes the NPXY motif of beta(1) integrin. Furthermore, our date suggest that an interaction between Val(787) and the hydrophobic pocket created by Leu(82) and Tyr(144) of Icap1 alpha forms the basis for the specificity of Icap1 alpha for the beta(1) integrin subunit.
-===THEORETICAL STRUCTURE OF ICAP1-ALPHA BOUND TO INTEGRIN BETA1 CYTOPLASMIC DOMAIN===
+Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin.,Chang DD, Hoang BQ, Liu J, Springer TA J Biol Chem. 2002 Mar 8;277(10):8140-5. Epub 2001 Dec 7. PMID:11741908<ref>PMID:11741908</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_11741908}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1k11" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 11741908 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_11741908}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Theoretical Model]]
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K11 OCA].
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:11741908</ref><references group="xtra"/>
 [[Category: Chang, D D]]
 [[Category: Hoang, B Q]]
 [[Category: Liu, J]]
 [[Category: Springer, T A]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  8 08:50:15 2010''