1gf2: Difference between revisions
New page: '''Theoretical Model''' The entry 1GF2 is a Theoretical Model titled 'TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS'. [[Category:Theoretical Model... |
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{{Theoretical_model}} | |||
==TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS== | |||
<StructureSection load='1gf2' size='340' side='right'caption='[[1gf2]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GF2 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gf2 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1gf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gf2 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Three-dimensional models for human insulinlike growth factors (IGF-I and IGF-II) have been constructed by using interactive molecular graphics. It is suggested that the two growth factors have structures in which the A and B chains and the hydrophobic cores are identical to those of insulin. The conformations of the connecting peptides and COOH-terminal extensions are predicted by statistical methods but the structures are limited by the constraints implied by the insulinlike part. The models explain the nonsuppressibility by anti-insulin antibodies of the IGFs and show that part of the insulin receptor-binding region is conserved, which explains the growth factors' ability to bind insulin receptors. | |||
Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.,Blundell TL, Bedarkar S, Humbel RE Fed Proc. 1983 Jun;42(9):2592-7. PMID:6189745<ref>PMID:6189745</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1gf2" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Bedarkar, S]] | |||
[[Category: Blundell, T L]] | |||
[[Category: Humbel, R E]] | |||