1gf2: Difference between revisions

m Protected "1gf2" [edit=sysop:move=sysop]
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Theoretical_model}}
{{Theoretical_model}}


[[Image:1gf2.png|left|200px]]
==TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS==
<StructureSection load='1gf2' size='340' side='right'caption='[[1gf2]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GF2 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gf2 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1gf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gf2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Three-dimensional models for human insulinlike growth factors (IGF-I and IGF-II) have been constructed by using interactive molecular graphics. It is suggested that the two growth factors have structures in which the A and B chains and the hydrophobic cores are identical to those of insulin. The conformations of the connecting peptides and COOH-terminal extensions are predicted by statistical methods but the structures are limited by the constraints implied by the insulinlike part. The models explain the nonsuppressibility by anti-insulin antibodies of the IGFs and show that part of the insulin receptor-binding region is conserved, which explains the growth factors' ability to bind insulin receptors.


{{STRUCTURE_1gf2|  PDB=1gf2  |  SCENE=  }}
Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.,Blundell TL, Bedarkar S, Humbel RE Fed Proc. 1983 Jun;42(9):2592-7. PMID:6189745<ref>PMID:6189745</ref>


===TERTIARY STRUCTURES, RECEPTOR BINDING, AND ANTIGENICITY OF INSULINLIKE GROWTH FACTORS===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_6189745}}
<div class="pdbe-citations 1gf2" style="background-color:#fffaf0;"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:006189745</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Theoretical Model]]
[[Category: Large Structures]]
[[Category: Bedarkar, S]]
[[Category: Bedarkar, S]]
[[Category: Blundell, T L]]
[[Category: Blundell, T L]]
[[Category: Humbel, R E]]
[[Category: Humbel, R E]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA