1fvb: Difference between revisions

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 {{Theoretical_model}}
-[[Image:1fvb.png|left|200px]]
+==MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN==
+<StructureSection load='1fvb' size='340' side='right'caption='[[1fvb]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FVB FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fvb FirstGlance], [https://www.ebi.ac.uk/pdbsum/1fvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fvb ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Models of the Fv portion (containing the variable regions of the heavy and light chains) of two monoclonal anti-alpha (1----6)dextran antibodies, W3129 and 19.1.2, were constructed from amino acid sequences and the known three-dimensional structures of the Fv portions of McPC603 and J539. The modeled combining site of W3129 has a protrusion on one side, formed by the long complementarity-determining region 1 of the light chain and the long complementarity-determining region 3 of the heavy chain, and has a cavity accommodating a glucose moiety. The model of the 19.1.2 site is basically flat with a shallow groove that can accommodate several internal glucose units. These results support the earlier conclusions, from ligand binding data, that W3129 has a cavity-type site, involving the terminal nonreducing glucose residue (endbinder), whereas 19.1.2 has a groove-type site.
-{{STRUCTURE_1fvb|  PDB=1fvb  |  SCENE=  }}
+Model-building study of the combining sites of two antibodies to alpha (1----6)dextran.,Padlan EA, Kabat EA Proc Natl Acad Sci U S A. 1988 Sep;85(18):6885-9. PMID:2457920<ref>PMID:2457920</ref>
-===MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_2457920}}
+<div class="pdbe-citations 1fvb" style="background-color:#fffaf0;"></div>
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:002457920</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Theoretical Model]]
+[[Category: Large Structures]]
 [[Category: Kabat, E A]]
 [[Category: Padlan, E A]]