FIS protein: Difference between revisions
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<StructureSection load='3jra' size='350' side='right' scene='54/542232/Cv/1' caption='FIS protein complex with DNA [[3jra]]'> | |||
'''FIS protein (Factor for Inversion Stimulation)''' or '''DNA-binding protein Fis''' is a regulatory protein in ''E. coli'' that activates ribosomal RNA transcription by binding to RNA promoter and enhances transcription by 5 to 10-fold. FIS binds to a sequence which stimulates hin-mediated DNA inversion and causes DNA bending. FIS affects the bacterial chromosome structure and the initiation of DNA replication. FIS exhibits autoregulation. It is abundant during ''E. coli'' exponential growth in rich medium and scarce during the stationary phase<ref>PMID:11278071</ref>. | |||
*<scene name='54/542232/Cv/2'>FIS protein complex with DNA</scene> ([[3jra]]). | |||
*<scene name='54/542232/Cv/5'>Protein/DNA interactions</scene>. | |||
'''FIS protein (Factor for Inversion Stimulation)''' is a regulatory protein in ''E. coli'' that activates ribosomal RNA transcription by binding to RNA promoter and enhances transcription by 5 to 10-fold. FIS binds to a sequence which stimulates hin-mediated DNA inversion and causes DNA bending. FIS affects the bacterial chromosome structure and the initiation of DNA replication. FIS exhibits autoregulation. It is abundant during ''E. coli'' exponential growth in rich medium and scarce during the stationary phase<ref>PMID:11278071</ref>. | *<scene name='54/542232/Cv/4'>Protein/DNA interactions (details, chain A)</scene>. | ||
*<scene name='54/542232/Cv/3'>Protein/DNA interactions (details, chain B)</scene>. | |||
</StructureSection> | |||
== 3D Structures of FIS protein == | == 3D Structures of FIS protein == | ||
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[[1f36]], [[1etk]], [[1eto]], [[1etq]], [[1etv]], [[1etw]], [[1etx]] – EcFIS (mutant) <br /> | [[1f36]], [[1etk]], [[1eto]], [[1etq]], [[1etv]], [[1etw]], [[1etx]] – EcFIS (mutant) <br /> | ||
[[1fip]] – EcFIS (mutant) + peptide <br /> | [[1fip]] – EcFIS (mutant) + peptide <br /> | ||
[[3iv5]], [[3jr9]], [[3jra]], [[3jrb]], [[3jrc]] [[3jrd]], [[3jre]], [[3jrf]], [[3jrg]], [[3jrh]], [[3jri]], [[4ihv]], [[4ihw]], [[4ihx]], [[4ihy]] – EcFIS + DNA <br /> | [[3iv5]], [[3jr9]], [[3jra]], [[3jrb]], [[3jrc]], [[3jrd]], [[3jre]], [[3jrf]], [[3jrg]], [[3jrh]], [[3jri]], [[4ihv]], [[4ihw]], [[4ihx]], [[4ihy]], [[5ds9]], [[5dtd]], [[5e3l]], [[5e3m]], [[5e3n]], [[5e3o]], [[6p0s]] – EcFIS + DNA <br /> | ||
[[6p0t]], [[6p0u]] – EcFIS + DNA + exicionase<br /> | |||
== References == | == References == | ||