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== Function ==
== Function ==


'''Adhesins''' (Adh) are surface components of bacteria which facillitate adhesion to surfaces or other cells.  Adh are specific surface recognition protein and are regarded as virulence factors.<ref>PMID:11043979</ref>  For trimeric autotransporter adhesin see [[EibD]].
'''Adhesins''' (Adh) are surface components of bacteria which facillitate adhesion to surfaces or other cells.  Adh are specific surface recognition protein and are regarded as virulence factors.<ref>PMID:11043979</ref>  '''FimH''' is the ''E. coli'' adhesin which is part of the type 1 pili of the bacteria.  The pili is composed of subunits '''FimF, FimG''' and '''FimD'''<ref>PMID:18369105</ref>.  The main Adhesins of the pathogen ''Mycoplasma genitalium'' are '''P110''' or '''Mgp-operon protein 3''' and '''P140'''<ref>PMID:30367053</ref>. See also [[Journal:Acta Cryst D:S2059798320008116|Novel structure of the N-terminal helical domain of BibA, a Group B Streptococcus immunogenic bacterial adhesin]].
 
For trimeric autotransporter adhesin see [[EibD]].


== Disease ==
== Disease ==


Bacterial pathogens use adhesins as a major factor in adhesion-based virulence.  Adhesins serve as vaccine targets since they are essential to infection<ref>PMID:10341176</ref>.
Bacterial pathogens use adhesins as a major factor in adhesion-based virulence.  Adhesins serve as vaccine targets since they are essential to infection<ref>PMID:10341176</ref>.
*<scene name='70/705684/Cv/2'>Adhesin PsaA complex with galactose, acetate and tert-butyl formate</scene> (PDB ID [[4f8p]]).<ref>PMID:23277582</ref>


</StructureSection>
== Structural highlights ==  
== 3D Structures of adhesin ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
<scene name='70/705684/Cv/4'>Adhesin PsaA complex with galactose, acetate and tert-butyl formate</scene> (PDB ID [[4f8p]])<ref>PMID:23277582</ref>
{{#tree:id=OrganizedByTopic|openlevels=0|
*<scene name='70/705684/Cv/3'>Galactose binding site</scene>. Water molecules are shown as red spheres.
*<scene name='70/705684/Cv/5'>Tert-butyl formate/Acetate binding site</scene>.


*Fimbrial adhesin  
== 3D Structures of adhesin ==
[[Adhesin 3D structures]]


**[[4k0o]], [[2bs8]], [[2bsc]], [[2bsb]] – EcF17b-G lectin domain – ''Escherichia coli''  <BR />
</StructureSection>
**[[4b4p]], [[4bwo]] – EcFedF lectin domain  <BR />
**[[4b4q]], [[4b4r]] – EcFedF lectin domain + hexasaccharide  <BR />
**[[4w6w]], [[4w6x]], [[4w6y]] – EcFedF lectin domain  + nanobody <BR />
**[[5afo]] – EcAdh  LF82  <BR />
**[[5jr4]] – EcAdh  + FIMG N-terminal <BR />
**[[5jqi]] – EcAdh  (mutant) + FIMG N-terminal <BR />
**[[3rfz]] – EcAdh  + FIMC + FIMD <BR />
**[[5fwr]] – EcAdh  lectin domain (mutant)  <BR />
**[[5aap]], [[5aal]] – EcAdh  lectin domain + anti-adhesive <BR />
**[[1psz]] – SpPsaA + Zn – ''Streptococcus pneumonia''<br />
**[[3ztt]] – SpPsaA + Mn<br />
**[[4utp]], [[4uto]] – SpPsaA + Cd<br />
**[[3zk7]] – SpPsaA <br />
**[[3zk8]], [[3zk9]], [[3zka]] – SpPsaA (mutant)<br />
**[[5cyl]] – PsaA subunit CUPB6 - ''Pseudomonas aeruginosa''<br />
 
*Epitheial adhesin
 
**[[4d3w]], [[4asl]], [[4af9]] – CgAdh epithelial 1 A domain – ''Candida glabrata''<br />
**[[4afc]], [[4afb]], [[4afa]] – CgAdh epithelial 1 A domain (mutant)<br />
**[[4cp2]], [[4cp1]], [[4cp0]] – CgAdh epithelial 9 A domain <br />
**[[4coz]], [[4coy]], [[4cow]], [[4cov]], [[4cou]] – CgAdh epithelial 6 A domain <br />
 
* Fimbrial adhesion complex
 
**[[2bs7]] – EcF17b-G lectin domain + chitobiose  <BR />
**[[3ffo]] – EcF17b-G lectin domain + GlcNac-Man  <BR />
**[[4b4q]], [[4b4r]] – EcFedF lectin domain + hexasaccharide  <BR />
**[[4w6w]], [[4w6x]], [[4w6y]] – EcFedF lectin domain  + nanobody <BR />
**[[4f8l]] – YpPsaA + galactose + inhibitor – ''Yersinia pestis'' <BR />
**[[4f8n]] – YpPsaA + galactose + phosphate choline <BR />
**[[4f8o]] – YpPsaA + lactose + inhibitor  <BR />
**[[4f8p]] – YpPsaA + galactose  <BR />
 
*Collagen adhesin (CAdh)
 
**[[1amx]] – SaCAdh CBD – ''Staphylococcus aureus''<br />
**[[1d2o]] – SaCAdh B1 repeat unit<br />
**[[1d2p]] – SaCAdh B1-B2 repeat units<br />
**[[2f68]] – SaCAdh extracellular domain<br />
**[[2f6a]] – SaCAdh extracellular domain + collagen<br />
**[[2okm]], [[2z1p]] – CAdh CBD – ''Enterococcus faecalis''<br />
**[[1p9h]] – YeYadA CBD – ''Yersinia enterocolitica''<br />
**[[3h7x]] – YeYadA stalk domain<br />
**[[3h7z]] – YeYadA stalk domain (mutant)<br />
**[[3lt6]], [[3lt7]] – YeYadA coiled coil<br />
**[[2lme]] – YeYadA coiled coil - NMR<br />
 
*Adhesin
 
**[[2odl]], [[2gr8]], [[2gr7]] – Adh secretion domain – ''Haemophilus influenzae''<br />
**[[4zh7]], [[4zh0]] – Adh BABA – ''Helicobacter pylori''<br />
**[[4usx]] – Adh trimeric autotransporter – ''Burkholderia pseudomallei''<br />
**[[3wqa]], [[3wpr]], [[3wpp]], [[3wpo]], [[3wpa]] – AcAdh trimeric autotransporter C-terminal – ''Acinetobacter''<br />
**[[3wp8]] – AcAdh trimeric autotransporter C-terminal (mutant)<br />
**[[4tsh]] – Adh surface protein – ''Streptococcus mutans''<br />
**[[4mee]] – EcAdh diffuse adherence C-terminal <br />
**[[3etw]] – FnAdh  A – ''Fusobacterium nucleatum'' <BR />
**[[3etz]], [[3ety]], [[3etx]] – FnAdh  A (mutant)  <BR />
**[[3d9x]] – Adh  A – ''Bartonella henselae'' <BR />
**[[2lwb]] – Adh  WI-1 – ''Ajellomyces dermatitidis'' <BR />
 
}}




Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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