Adhesin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='4f8p' size='350' side='right' caption='Adhesin PsaA complex with galactose (PDB ID [[4f8p]])' scene='70/705684/Cv/1'>
+<StructureSection load='' size='350' side='right' caption='Adhesin PsaA complex with tert-butyl formate and galactose (stick model) (PDB ID [[4f8p]])' scene='70/705684/Cv/1'>
 == Function ==
-'''Adhesins''' (Adh) are surface components of bacteria which facillitate adhesion to surfaces or other cells.  Adh are specific surface recognition protein and are regarded as virulence factors.<ref>PMID:11043979</ref>  For trimeric autotransporter adhesin see [[EibD]].
+'''Adhesins''' (Adh) are surface components of bacteria which facillitate adhesion to surfaces or other cells.  Adh are specific surface recognition protein and are regarded as virulence factors.<ref>PMID:11043979</ref>  '''FimH''' is the ''E. coli'' adhesin which is part of the type 1 pili of the bacteria.  The pili is composed of subunits '''FimF, FimG''' and '''FimD'''<ref>PMID:18369105</ref>.  The main Adhesins of the pathogen ''Mycoplasma genitalium'' are '''P110''' or '''Mgp-operon protein 3''' and '''P140'''<ref>PMID:30367053</ref>. See also [[Journal:Acta Cryst D:S2059798320008116|Novel structure of the N-terminal helical domain of BibA, a Group B Streptococcus immunogenic bacterial adhesin]].
+For trimeric autotransporter adhesin see [[EibD]].
 == Disease ==
-Bacterial pathogens use adhesins as a major factor in adhesion-based virulence.  Adhesins serve as vaccine targets since they are essential to infection.
+Bacterial pathogens use adhesins as a major factor in adhesion-based virulence.  Adhesins serve as vaccine targets since they are essential to infection<ref>PMID:10341176</ref>.
-*<scene name='70/705684/Cv/2'>Adhesin PsaA complex with galactose, acetate and tert-butyl formate</scene> (PDB ID [[4f8p]]).<ref>PMID:23277582</ref>
-</StructureSection>
-== 3D Structures of adhesin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== Structural highlights ==
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Fimbrial adhesin
+<scene name='70/705684/Cv/4'>Adhesin PsaA complex with galactose, acetate and tert-butyl formate</scene> (PDB ID [[4f8p]])<ref>PMID:23277582</ref>
+*<scene name='70/705684/Cv/3'>Galactose binding site</scene>. Water molecules are shown as red spheres.
+*<scene name='70/705684/Cv/5'>Tert-butyl formate/Acetate binding site</scene>.
-**[[4k0o]], [[2bs8]] – EcF17b-G lectin domain – ''Escherichia coli''  <BR />
+== 3D Structures of adhesin ==
-**[[4b4p]], [[4bwo]] – EcFedF lectin domain   <BR />
+[[Adhesin 3D structures]]
-**[[1psz]] – SpPsaA + Zn – ''Streptococcus pneumonia''<br />
-**[[3ztt]] – SpPsaA + Mn<br />
-**[[4utp]], [[4uto]] – SpPsaA + Cd<br />
-**[[3zk7]] – SpPsaA <br />
-**[[3zk8]], [[3zk9]], [[3zka]] – SpPsaA (mutant)<br />
-**[[5cyl]] – PsaA subunit CUPB6 - ''Pseudomonas aeruginosa''<br />
-* Fimbrial adhesion complex
+</StructureSection>
-**[[2bs7]] – EcF17b-G lectin domain + chitobiose  <BR />
-**[[3ffo]] – EcF17b-G lectin domain + GlcNac-Man  <BR />
-**[[4b4q]], [[4b4r]] – EcFedF lectin domain + hexasaccharide  <BR />
-**[[4w6w]], [[4w6x]], [[4w6y]] – EcFedF lectin domain  + nanobody <BR />
-**[[4f8l]] – YpPsaA + galactose + inhibitor – ''Yersinia pestis'' <BR />
-**[[4f8n]] – YpPsaA + galactose + phosphate choline <BR />
-**[[4f8o]] – YpPsaA + lactose + inhibitor  <BR />
-**[[4f8p]] – YpPsaA + galactose  <BR />
-*Collagen adhesin (CAdh)
-**[[1amx]] – SaCAdh CBD – ''Staphylococcus aureus''<br />
-**[[1d2o]] – SaCAdh B1 repeat unit<br />
-**[[1d2p]] – SaCAdh B1-B2 repeat units<br />
-**[[2f68]] – SaCAdh extracellular domain<br />
-**[[2f6a]] – SaCAdh extracellular domain + collagen<br />
-**[[2okm]] – CAdh CBD – ''Enterococcus faecalis''<br />
-**[[1p9h]] – YeYadA CBD – ''Yersinia enterocolitica''<br />
-**[[3h7x]] – YeYadA stalk domain<br />
-**[[3h7z]] – YeYadA stalk domain (mutant)<br />
-**[[3lt6]], [[3lt7]] – YeYadA coiled coil<br />
-**[[2lme]] – YeYadA coiled coil - NMR<br />
-*Adhesin
-**[[2odl]] – Adh secretion domain – ''Haemophilus influenzae''<br />
-}}