1dcx: Difference between revisions
New page: '''Theoretical Model''' The entry 1DCX is a Theoretical Model titled 'MOLECULAR MODEL OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2'. [[Category:Theoretical Model]... |
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{{Theoretical_model}} | |||
==MOLECULAR MODEL OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2== | |||
<StructureSection load='1dcx' size='340' side='right'caption='[[1dcx]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DCX FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dcx FirstGlance], [https://www.ebi.ac.uk/pdbsum/1dcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dcx ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Cyclooxygenases are bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, thromboxanes and other eicosanoids. The two known cyclooxygenases isoforms share a high degree of amino-acid sequence similarity, structural topology and an identical catalytic mechanism. Cyclooxygenase enzymes catalyse two sequential reactions in spatially distinct, but mechanistically coupled active sites. The initial cyclooxygenase reaction converts arachidonic acid (which is achiral) to prostaglandin G2 (which has five chiral centres). The subsequent peroxidase reaction reduces prostaglandin G2 to prostaglandin H2. Here we report the co-crystal structures of murine apo-cyclooxygenase-2 in complex with arachidonic acid and prostaglandin. These structures suggest the molecular basis for the stereospecificity of prostaglandin G2 synthesis. | |||
Structural insights into the stereochemistry of the cyclooxygenase reaction.,Kiefer JR, Pawlitz JL, Moreland KT, Stegeman RA, Hood WF, Gierse JK, Stevens AM, Goodwin DC, Rowlinson SW, Marnett LJ, Stallings WC, Kurumbail RG Nature. 2000 May 4;405(6782):97-101. PMID:10811226<ref>PMID:10811226</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1dcx" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Gierse, J K]] | |||
[[Category: Goodwin, D C]] | |||
[[Category: Kiefer, J R]] | |||
[[Category: Kurumbail, R G]] | |||
[[Category: Marnett, L J]] | |||
[[Category: Moreland, K T]] | |||
[[Category: Pawlitz, J L]] | |||
[[Category: Rowlinson, S W]] | |||
[[Category: Stallings, W C]] | |||
[[Category: Stegeman, R A]] | |||
[[Category: Stevens, A M]] | |||