SN2 reaction (Hebrew): Difference between revisions

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Veronika Pelekhov

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 <jmol><jmolLink><script>anim mode once; frame range 1 10; delay 0.5; frame play</script><text>התגובה מתחילה</text></jmolLink></jmol> על ידי יצירת מצב ביניים - יון הכלור (הנוקלאופיל) נקשר בקשר חלש למולקולת המתנול (הסובסטרט) וקבוצת הידרוקסיל (הקבוצה העוזבת) מתחילה להתנתק ממולקולת הסובסטרט. במצב הביניים ניתן לראות כי שתי הקבוצות קשורות לסובסטרט בו-זמנית.
-<jmol><jmolLink><script>anim mode once; frame range 11 20; delay 0.5; frame play</script><text>בהמשך התגובה</text></jmolLink></jmol> הקבוצה העוזבת ניתקת לחלוטין מהסובסטרט במקביל להיווצרות הקשר הסופי עם הנוקלאופיל.
+<jmol><jmolLink><script>anim mode once; frame range 11 20; delay 0.5; frame play</script><text>בהמשך התגובה</text></jmolLink></jmol> הקבוצה העוזבת ניתקת לחלוטין מהסובסטרט במקביל להיווצרות הקשר הסופי עם הנוקלאופיל וקבלת התוצר
 .</p>
 [[Image:reaction_scheme_sn2.jpg|550px]] <br>
+<p dir='rtl'>
+ניתן לעבור בין הייצוגים השונים של המולקולות באנימציה ולשלוט במאפייני האנימציה על ידי לחיצה על הכפתורים שלמטה
+.</p>
-SN2 reaction is a basic reaction type in organic chemistry. The letter S<sub>N</sub> stands for nulceophilic Substitution, the number 2 stands for bimolecular, with both reactions partners are involved in the reaction rate determining step. It also exists an S<sub>N</sub>1 reaction; here, only one reaction partner is involved in this step. On the other side, SN2 reactions are characterized by exchanging substituents. The substituent that leaves the molecule is called leaving group.
-Typically, alkanes with a substituent in primary position undergo S<sub>N</sub>2 reactions. In contrast to a S<sub>N</sub>1 reaction, no stable carbo cation can be formed, therefore, another way is taken.
-The S<sub>N</sub>2 <jmol><jmolLink><script>anim mode once; frame range 1 10; delay 0.5; frame play</script><text>reaction starts</text></jmolLink></jmol> by establishing a so called ''intermediate'' state, with both educts comeing close to each other. By this, the bond of the leaving group is partly broken, and the bond to the new group is partly formed. The formation of this intermediate state is the rate determining step of the reaction.
-In the <jmol><jmolLink><script>anim mode once; frame range 11 20; delay 0.5; frame play</script><text>second step</text></jmolLink></jmol>, the bond of the leaving group is completely broken, and at the same time the bond to the new substituent is completely formed.
-The S<sub>N</sub>2 reaction has a very interesting stereochemistry inversion of the stereocenter<ref>PMID: 27505286 </ref> with an animated example of the substitution of chloride and methanol shown. Please click on the buttons below to '''animate''' the reaction with different representations. Use the '''popup''' button to enlarge the view and the '''quality''' button to turn on anti-aliasing.
 <jmol>
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 ===See also===
+[[SN1 reaction (Hebrew)]]
 [[SN1_reaction|S<sub>N</sub>1 reaction: Substitution of Cl<sup>&minus;</sup> and ''tert''-Butanol ]]