Dual specificity phosphatase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

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 == Function ==
-'''Dual specificity phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>.  There are several DUSP enzymes in mammals sharing a common catalytic mechanism.  The DUSP include:<br />
+'''Dual specificity phosphatase''' or '''Dual specificity protein phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>.  There are several DUSP enzymes in mammals sharing a common catalytic mechanism.  The DUSP include:<br />
 •	'''Slingshot phosphatase'''<ref>PMID:17848544</ref><br />
 •	'''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br />
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 <scene name='44/444621/Cv/6'>Tripeptide binding site</scene> in human Cdc14B2 (PDB code [[1ohe]]).<ref>PMID:12853468</ref>
-</StructureSection>
 ==3D structures of dual specificity phosphatase==
+[[Dual specificity phosphatase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Dual specificity phosphatase
-**[[4y2e]] – hDUSP 7 catalytic domain (mutant) - human<br />
-**[[5xjv]] – hDUSP 13A (mutant) <br />
-**[[4yr8]] – hDUSP 16 residues 156-301 + MAPK 8<br />
-**[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />
-**[[5gtj]]  – hDUSP 26 (mutant) <br />
-**[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />
-*Slingshot phosphatase (SSH)
-**[[2nt2]]  – hSSH-2L catalytic domain - human<br />
-*Phosphatase of regenerating liver (PRL)
-**[[1xm2]]  – hPRL-1 (mutant)<br />
-**[[1zck]], [[1x24]]  – rPRL-1 - rat<br />
-**[[1zcl]] – rPRL-1 (mutant)<br />
-**[[1r6h]], [[1v3a]], [[2mbc]]  – hPRL-3 - NMR<br />
-*Cdc14
-**[[1ohc]], [[1ohd]]  – hCdc14B2 core domain <br />
-**[[1ohe]]  – hCdc14B2 core domain + peptide<br />
-*Cdc25
-**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]]  – hCdc25B catalytic domain <br />
-**[[2a2k]], [[2ifd]], [[2ifv]]  – hCdc25B catalytic domain (mutant)<br />
-*Phosphoinositide phosphatase PTEN
-**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />
-*Myotubularin-related protein (MTMR)
-**[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br />
-**[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br />
-**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
-**[[2yf0]] – hMTMR6<br />
-*MAPK phosphatase see [[MAP kinase phosphatase]]
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]