2p4d: Difference between revisions

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-{{Seed}}
-[[Image:2p4d.png|left|200px]]
-<!--
+==Structure-assisted discovery of Variola major H1 phosphatase inhibitors==
-The line below this paragraph, containing "STRUCTURE_2p4d", creates the "Structure Box" on the page.
+<StructureSection load='2p4d' size='340' side='right'caption='[[2p4d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2p4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Varv Varv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P4D FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4d OCA], [https://pdbe.org/2p4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p4d RCSB], [https://www.ebi.ac.uk/pdbsum/2p4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p4d ProSAT]</span></td></tr>
-{{STRUCTURE_2p4d|  PDB=2p4d  |  SCENE=  }}
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/DUSP_VAR67 DUSP_VAR67]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/2p4d_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p4d ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Variola major virus, the causative agent of smallpox, encodes the dual-specificity H1 phosphatase. Because this enzyme is essential for the production of mature virus particles, it is an attractive molecular target for the development of therapeutic countermeasures for this potential agent of bioterrorism. As a first step in this direction, the crystal structure of H1 phosphatase has been determined at a resolution of 1.8 A. In silico screening methods have led to the identification of several small molecules that inhibit Variola H1 phosphatase with IC(50) values in the low micromolar range. These molecules provide novel leads for future drug development.
-===Structure-assisted discovery of Variola major H1 phosphatase inhibitors===
+Structure-assisted discovery of Variola major H1 phosphatase inhibitors.,Phan J, Tropea JE, Waugh DS Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):698-704. Epub 2007, May 15. PMID:17505108<ref>PMID:17505108</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2p4d" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_17505108}}, adds the Publication Abstract to the page
+*[[MAP kinase phosphatase|MAP kinase phosphatase]]
-(as it appears on PubMed at http://www.pubmed.gov), where 17505108 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17505108}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-P4D is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Variola_virus Variola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4D OCA].
+[[Category: Varv]]
+[[Category: Phan, J]]
-==Reference==
+[[Category: Tropea, J E]]
-<ref group="xtra">PMID:17505108</ref><references group="xtra"/>
+[[Category: Waugh, D S]]
-[[Category: Variola virus]]
-[[Category: Phan, J.]]
-[[Category: Tropea, J E.]]
-[[Category: Waugh, D S.]]
 [[Category: Drug design]]
 [[Category: Dual specificity phosphatase]]
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 [[Category: Hydrolase]]
 [[Category: Small pox]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:27:12 2009''