Metabotropic glutamate receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Michal Harel, Nikki Hunter, Alexander Berchansky

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 *'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C.  For details see [[Metabotropic glutamate receptor 5]].<br />
 *'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br />
-*'''Metabotropic glutamate receptor 7''' and '''metabotropic glutamate receptor 8'''belong to group III and inhibits adenylate cyclase activity.<br />
+*'''Metabotropic glutamate receptor 7''' and '''metabotropic glutamate receptor 8''' belong to group III and inhibits adenylate cyclase activity.<br />
 Articles in Proteopedia concerning Toll-like Receptors include:
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 == Structural highlights ==
-<scene name='46/464134/Cv/2'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules shown as red spheres.
+<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres.
-</StructureSection>
 ==3D structures of metabotropic glutamate receptor ==
+[[Metabotropic glutamate receptor 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Metabotropic glutamate receptor 1
-**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br />
-**[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br />
-**[[4or2]] - hMGluR1/cytochrome b526<br />
-**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br />
-**[[1iss]] - rMGluR1 LBD + antagonist<br />
-*Metabotropic glutamate receptor 2
-**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />
-**[[5kzq]], [[5kzn]] – hMGluR2 LBD + antagonist<br />
-**[[5cni]] – hMGluR2 LBD + Glu <br />
-**[[5cnj]] – hMGluR2 LBD + Glu analog<br />
-*Metabotropic glutamate receptor 3
-**[[5cnk]] – hMGluR3 LBD + Glu <br />
-**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
-**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
-**[[3sm9]] - hMGluR3 + antagonist<br />
-**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br />
-**[[5cnm]] – hMGluR3 LBD + Glu analog<br />
-*Metabotropic glutamate receptor 5
-**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br />
-**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />
-**[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br />
-*Metabotropic glutamate receptor 7
-**[[5c5c]] – hMGluR7 LBD (mutant)<br />
-**[[3mq4]] – hMGluR7 LBD + antagonist<br />
-*Metabotropic glutamate receptor 8
-**[[6bsz]] – hMGluR8 LBD + Glu <br />
-**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br />
-}}
 ==See Also==
 [[Membrane Channels & Pumps]] <br/>
-[[Ionotropic_Glutamate_Receptors]]<br/>
+[[Ionotropic Glutamate Receptors]]<br/>
 [[Alzheimer's Disease]]<br/>
+* [[G protein-coupled receptor]]
+*[[Receptor]]
+*[[Transmembrane (cell surface) receptors]]
 == References ==
 <references/>
 [[Category:Topic Page]]