Metabotropic glutamate receptor: Difference between revisions
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< | <StructureSection load='1ewk' size='350' side='right' scene='46/464134/Cv/1' caption='Structure of the glycosylated rat binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate, Hepes and Mg+2 ions ([[1ewk]])'> | ||
== Function == | == Function == | ||
[[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | [[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | ||
*'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C.<br /> | *'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C. For details see [[Metabotropic glutamate receptor 5]].<br /> | ||
*'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br /> | *'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br /> | ||
*'''Metabotropic glutamate receptor 7''' | *'''Metabotropic glutamate receptor 7''' and '''metabotropic glutamate receptor 8''' belong to group III and inhibits adenylate cyclase activity.<br /> | ||
Articles in Proteopedia concerning Toll-like Receptors include: | Articles in Proteopedia concerning Toll-like Receptors include: | ||
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*[[Membrane proteins]] | *[[Membrane proteins]] | ||
<br /> | <br /> | ||
== Relevance == | |||
GluR are targets for Parkinson's disease drugs<ref>PMID:19702565</ref> as well as for Alzheimer's disease, depression, anxiety and schizophrenia<ref>PMID:20055706</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
Glutamate is bound to GluR1 in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. | <scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres. | ||
==3D structures of metabotropic glutamate receptor == | ==3D structures of metabotropic glutamate receptor == | ||
[[Metabotropic glutamate receptor 3D structures]] | |||
</StructureSection> | |||
==See Also== | ==See Also== | ||
[[Membrane Channels & Pumps]] <br/> | [[Membrane Channels & Pumps]] <br/> | ||
[[ | [[Ionotropic Glutamate Receptors]]<br/> | ||
[[Alzheimer's Disease]]<br/> | [[Alzheimer's Disease]]<br/> | ||
* [[G protein-coupled receptor]] | |||
*[[Receptor]] | |||
*[[Transmembrane (cell surface) receptors]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||