Metabotropic glutamate receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Michal Harel, Nikki Hunter, Alexander Berchansky

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-[[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signalling cascade involving G proteins. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]].
+<StructureSection load='1ewk' size='350' side='right' scene='46/464134/Cv/1' caption='Structure of the glycosylated rat binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate, Hepes and Mg+2 ions ([[1ewk]])'>
-<Structure load='1isr' size='500' side='right' caption='Structure of the binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate and gadolinium ions ([[1isr]])' scene=' '/>
+== Function ==
+[[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties.  See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]].
+*'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C.  For details see [[Metabotropic glutamate receptor 5]].<br />
+*'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br />
+*'''Metabotropic glutamate receptor 7''' and '''metabotropic glutamate receptor 8''' belong to group III and inhibits adenylate cyclase activity.<br />
 Articles in Proteopedia concerning Toll-like Receptors include:
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 *[[Membrane proteins]]
 <br />
-==3D structures of metabotropic glutamate receptor ==
+== Relevance ==
+GluR are targets for Parkinson's disease drugs<ref>PMID:19702565</ref> as well as for Alzheimer's disease, depression, anxiety and schizophrenia<ref>PMID:20055706</ref>.
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== Structural highlights ==
-{{#tree:id=OrganizedByTopic|openlevels=0|
+<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres.
-*Metabotropic glutamate receptor 1
+==3D structures of metabotropic glutamate receptor ==
+[[Metabotropic glutamate receptor 3D structures]]
-**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br />
-**[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br />
-**[[4or2]] - hMGluR1/cytochrome b526<br />
-**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br />
-**[[1iss]] - rMGluR1 LBD + antagonist<br />
-*Metabotropic glutamate receptor 2
-**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />
-*Metabotropic glutamate receptor 3
-**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
-**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
-**[[3sm9]] - hMGluR3 + antagonist<br />
-**[[4xar]] – hMGluR3 LBD + agonist<br />
-*Metabotropic glutamate receptor 5
-**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />
+</StructureSection>
-*Metabotropic glutamate receptor 7
-**[[3mq4]] – hMGluR7 LBD + antagonist<br />
-}}
 ==See Also==
 [[Membrane Channels & Pumps]] <br/>
-[[Ionotropic_Glutamate_Receptors]]<br/>
+[[Ionotropic Glutamate Receptors]]<br/>
 [[Alzheimer's Disease]]<br/>
+* [[G protein-coupled receptor]]
-* [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]
+*[[Receptor]]
+*[[Transmembrane (cell surface) receptors]]
+== References ==
+<references/>
 [[Category:Topic Page]]