Beta-2 adrenergic receptor: Difference between revisions

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<Structure load='3pds' size='350' frame='true' side='right'  caption='Human β-2 adrenoceptor (Cannabinoid Receptor 1) complex with agonist, cholesterol and sulfate (PDB code [[3pds]])' scene='71/716602/Normal/1' />
<StructureSection load='' size='400' side='right'  caption='Human β-2 adrenoceptor (Cannabinoid Receptor 1) complex with agonist, cholesterol and sulfate (PDB code [[3pds]])' scene='71/716602/Normal/1'>
 


==Abstract==
==Abstract==
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CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoid, produce the harmful side effect of extreme anxiety.  
CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoid, produce the harmful side effect of extreme anxiety.  


See [[Treatments:Hypertension]].
See [[Treatments:Hypertension]]
 
[[Group:SMART:A Physical Model of the beta-Adrenergic Receptor]]
== 3D structure of β-2 adrenoceptor ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[2rh1]], [[5d5a]], [[5d5b]] – hB2AR/lysozyme (mutant) – human<br />
== 3D structure of β-2 adrenergic receptor ==
[[2r4r]], [[2r4s]], [[3kj6]] – hB2AR + antibody<br />
[[Adrenergic receptor]]
[[4lde]] – hB2AR/lysozyme (mutant) + antibody<br />
[[4ldl]] – hB2AR/lysozyme (mutant) + antibody + proterenol derivative<br />
[[4ldo]] – hB2AR/lysozyme (mutant) + antibody + adrenaline<br />
[[3sn6]] – hB2AR (mutant) + antibody + guanine nucleotide-binding protein<br />
[[4qkx]] – hB2AR (mutant) + R9 protein<br />
[[4gbr]] – hB2AR (mutant) + lysozyme <br />
[[3d4s]] – hB2AR/lysozyme (mutant) + cholesterol<br />
[[3ny8]], [[3ny9]], [[3pds]] – hB2AR/lysozyme (mutant) + agonist<br />
[[3nya]] – hB2AR/lysozyme (mutant) + antagonist<br />




See also:
* [[G protein-coupled receptor]]
*[[Receptor]]
*[[Transmembrane (cell surface) receptors]]
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Tala Curry, Michal Harel, Jaime Prilusky, Joel L. Sussman, Alexander Berchansky
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