Alpha-bungarotoxin: Difference between revisions
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<StructureSection load='2abx' size='350' side='right' scene='' caption=''> | |||
=Alpha-Bungarotoxin= | =Alpha-Bungarotoxin= | ||
'''Alpha-[[Bungarotoxin]]''' (α-BGT) is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake belonging to a group commonly known as kraits. Belonging to the Elapidae Family, which consist of cobras, kraits, tiger snakes, and mambas, the venom of ''Bungarus multicuntus'' is a complex mixture of many different molecules<ref name="main">PMID: 3507686</ref> α-BGT belongs to a family of homologous proteins that act as a neurotoxic agent in the venom of these snakes. α-BGT is known to bind irreversibly to the acetylcholine receptor found at the neuromuscular junction, causing respiratory failure, paralysis, and death, as well as play an antagonstic role in binding the α7 nicotinic acetylcholine receptor in the brain. | '''Alpha-[[Bungarotoxin]]''' (α-BGT) is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake belonging to a group commonly known as kraits. Belonging to the Elapidae Family, which consist of cobras, kraits, tiger snakes, and mambas, the venom of ''Bungarus multicuntus'' is a complex mixture of many different molecules<ref name="main">PMID: 3507686</ref> α-BGT belongs to a family of homologous proteins that act as a neurotoxic agent in the venom of these snakes. α-BGT is known to bind irreversibly to the acetylcholine receptor found at the neuromuscular junction, causing respiratory failure, paralysis, and death, as well as play an antagonstic role in binding the α7 nicotinic acetylcholine receptor in the brain. | ||
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Response to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref>PMID: 8478687</ref>, which are mediated by two major classes of receptors: Ganglionic type, and neuromuscular type, which pharmacological analysis of seizure genesis and habituation in the rat brain is thought to be mediated by the latter type <ref>PMID: 2813485</ref>. α-BGT demonstrates this relationship due to its prominent binding in the CA3 region of the hippocampus <ref>PMID: 626914</ref>. | Response to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref>PMID: 8478687</ref>, which are mediated by two major classes of receptors: Ganglionic type, and neuromuscular type, which pharmacological analysis of seizure genesis and habituation in the rat brain is thought to be mediated by the latter type <ref>PMID: 2813485</ref>. α-BGT demonstrates this relationship due to its prominent binding in the CA3 region of the hippocampus <ref>PMID: 626914</ref>. | ||
See also: | |||
*[[Receptor]] | |||
*[[Transmembrane (cell surface) receptors]] | |||
*[[Ionotropic receptors]] | |||
</StructureSection> | |||
==3D structures of Alpha-bungarotoxin== | ==3D structures of Alpha-bungarotoxin== | ||