1an3: Difference between revisions
New page: '''Theoretical Model''' The entry 1AN3 is a Theoretical Model titled 'THE RABBIT PROLACTIN HORMONE COMPLEXED WITH THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR, THEORETICAL MODEL'. [[Category... |
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{{Theoretical_model}} | |||
==THE RABBIT PROLACTIN HORMONE COMPLEXED WITH THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR, THEORETICAL MODEL== | |||
<StructureSection load='1an3' size='340' side='right'caption='[[1an3]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AN3 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1an3 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1an3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1an3 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The pituitary hormone prolactin (prl) is implicated in a number of biological functions, especially lactation, which is mediated through specific lactogenic receptors (PrlR). Human growth hormone (hGH) is also a pituitary hormone responsible for linear growth. While the growth hormone receptor (hGHR) binds only hGH, hPrlR can interact with both hGH and hPrl. Using structural information from the human growth hormone (hGH)/receptor (hGHR) complex, we modeled by homology a complex between rabbit prolactin hormone (rbPrl) and its receptor (rbPrlR). While the somatogenic hormone/somatogenic receptor (hGH/hGHR) and somatogenic hormone/lactogenic receptor (hGH/hPrlR) interactions are now known and well studied, here we propose a model for the interaction of the lactogenic hormone with its receptor (rbPrl/rbPrlR), and compare these three kinds of ligand/receptor interaction. We identified residues contributing to the active site and tested the potential dimerization of the receptor. Biochemical studies and information deduced from the modeled complex do not exclude a homodimeric form but point to a functional heterodimeric complex. | |||
Homology modeling of rabbit prolactin hormone complexed with its receptor.,Halaby D, Thoreau E, Djiane J, Mornon JP Proteins. 1997 Mar;27(3):459-68. PMID:9094747<ref>PMID:9094747</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1an3" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Halaby, D]] | |||
[[Category: Mornon, J P]] | |||