1an3: Difference between revisions
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{{Theoretical_model}} | |||
==THE RABBIT PROLACTIN HORMONE COMPLEXED WITH THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR, THEORETICAL MODEL== | ==THE RABBIT PROLACTIN HORMONE COMPLEXED WITH THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR, THEORETICAL MODEL== | ||
<StructureSection load='1an3' size='340' side='right' caption='[[1an3]]' scene=''> | <StructureSection load='1an3' size='340' side='right'caption='[[1an3]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AN3 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1an3 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1an3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1an3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Halaby, D]] | [[Category: Halaby, D]] | ||
[[Category: Mornon, J P]] | [[Category: Mornon, J P]] | ||
Latest revision as of 12:47, 26 May 2021
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THE RABBIT PROLACTIN HORMONE COMPLEXED WITH THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR, THEORETICAL MODELTHE RABBIT PROLACTIN HORMONE COMPLEXED WITH THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR, THEORETICAL MODEL
Structural highlights
Publication Abstract from PubMedThe pituitary hormone prolactin (prl) is implicated in a number of biological functions, especially lactation, which is mediated through specific lactogenic receptors (PrlR). Human growth hormone (hGH) is also a pituitary hormone responsible for linear growth. While the growth hormone receptor (hGHR) binds only hGH, hPrlR can interact with both hGH and hPrl. Using structural information from the human growth hormone (hGH)/receptor (hGHR) complex, we modeled by homology a complex between rabbit prolactin hormone (rbPrl) and its receptor (rbPrlR). While the somatogenic hormone/somatogenic receptor (hGH/hGHR) and somatogenic hormone/lactogenic receptor (hGH/hPrlR) interactions are now known and well studied, here we propose a model for the interaction of the lactogenic hormone with its receptor (rbPrl/rbPrlR), and compare these three kinds of ligand/receptor interaction. We identified residues contributing to the active site and tested the potential dimerization of the receptor. Biochemical studies and information deduced from the modeled complex do not exclude a homodimeric form but point to a functional heterodimeric complex. Homology modeling of rabbit prolactin hormone complexed with its receptor.,Halaby D, Thoreau E, Djiane J, Mornon JP Proteins. 1997 Mar;27(3):459-68. PMID:9094747[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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