Sandbox GGC9: Difference between revisions
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 23: | Line 23: | ||
The zinc site plays an important role in DNA cleavage; without the zinc site the DNA would not be able to be cleaved and would not form the essential hairpin structure.[5]<scene name='75/752271/Zinc_ligands/1'>Zinc Ligands</scene> | The zinc site plays an important role in DNA cleavage; without the zinc site the DNA would not be able to be cleaved and would not form the essential hairpin structure.[5]<scene name='75/752271/Zinc_ligands/1'>Zinc Ligands</scene> | ||
<scene name='75/752271/Zinc_finger_motif/1'>Ring Zinc Finger</scene> of dimerization domain. | |||
| Line 28: | Line 30: | ||
In addition to the catalytic function of aspartic acid residues at 600 and 708 | In addition to the catalytic function of aspartic acid residues at 600 and 708. | ||
Researchers have discovered a trio of residues that are necessary for the DNA cleavage during V(D)J recombination. This trio includes the two catalytic residues as well as a Glutamic acid residue at position 962.[8]<scene name='75/752271/Dde_motif/1'>Residues responsible for DNA cleavage</scene> | |||
Residues 265-383 on RAG 1 contain ubiquitin ligase activity. <scene name='75/752271/Ubiquitin_ligase_activity/1'>Ubiquitin activity</scene> | Residues 265-383 on RAG 1 contain ubiquitin ligase activity. <scene name='75/752271/Ubiquitin_ligase_activity/1'>Ubiquitin activity</scene> | ||