7atz: Difference between revisions
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==G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite== | |||
<StructureSection load='7atz' size='340' side='right'caption='[[7atz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7atz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ATZ FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7atz OCA], [https://pdbe.org/7atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7atz RCSB], [https://www.ebi.ac.uk/pdbsum/7atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7atz ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The KCNN4 gene encoding a potassium channel protein whose expression has been correlated with tumor progression was found to comprise a guanine-rich minisatellite region with the ability to form a putative G-quadruplex (G4). Given the suggested regulatory role of G4s in gene expression, G-quadruplex formation for the polymorphic first repeat of the minisatellite was studied by nuclear magnetic resonance spectroscopy. A stable G-quadruplex of a truncated mutant sequence was shown to represent one of several coexisting species of the wild-type sequence. The high-resolution structure features a noncanonical G4 with a broken G-column and a V-shaped loop. The presence of a 3'-flanking thymidine interacting with the lateral loop preceding the V loop seems to be critical for the formation of this G4 topology. On the contrary, an additional 5'-flanking residue disfavored but still allowed folding into the V-loop structure. The latter may therefore serve as a putative therapeutic target in strategies for G4-based modulation of KCNN4 expression. | |||
First Tandem Repeat of a Potassium Channel KCNN4 Minisatellite Folds into a V-Loop G-Quadruplex Structure.,Vianney YM, Weisz K Biochemistry. 2021 Apr 12. doi: 10.1021/acs.biochem.1c00043. PMID:33844501<ref>PMID:33844501</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7atz" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vianney, Y M]] | |||
[[Category: Weisz, K]] | |||
[[Category: Dna]] | |||
[[Category: G-quadruplex]] | |||
[[Category: V-loop]] | |||
Latest revision as of 08:30, 28 April 2021
G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatelliteG-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite
Structural highlights
Publication Abstract from PubMedThe KCNN4 gene encoding a potassium channel protein whose expression has been correlated with tumor progression was found to comprise a guanine-rich minisatellite region with the ability to form a putative G-quadruplex (G4). Given the suggested regulatory role of G4s in gene expression, G-quadruplex formation for the polymorphic first repeat of the minisatellite was studied by nuclear magnetic resonance spectroscopy. A stable G-quadruplex of a truncated mutant sequence was shown to represent one of several coexisting species of the wild-type sequence. The high-resolution structure features a noncanonical G4 with a broken G-column and a V-shaped loop. The presence of a 3'-flanking thymidine interacting with the lateral loop preceding the V loop seems to be critical for the formation of this G4 topology. On the contrary, an additional 5'-flanking residue disfavored but still allowed folding into the V-loop structure. The latter may therefore serve as a putative therapeutic target in strategies for G4-based modulation of KCNN4 expression. First Tandem Repeat of a Potassium Channel KCNN4 Minisatellite Folds into a V-Loop G-Quadruplex Structure.,Vianney YM, Weisz K Biochemistry. 2021 Apr 12. doi: 10.1021/acs.biochem.1c00043. PMID:33844501[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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