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[[Image:2if2.gif|left|200px]]


{{Structure
==Crystal Structure of the Putative Dephospho-CoA Kinase from Aquifex aeolicus, Northeast Structural Genomics Target QR72.==
|PDB= 2if2 |SIZE=350|CAPTION= <scene name='initialview01'>2if2</scene>, resolution 3.00&Aring;
<StructureSection load='2if2' size='340' side='right'caption='[[2if2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
<table><tr><td colspan='2'>[[2if2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IF2 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dephospho-CoA_kinase Dephospho-CoA kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24]  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|GENE= coaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">coaE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dephospho-CoA_kinase Dephospho-CoA kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24] </span></td></tr>
'''Crystal Structure of the Putative Dephospho-CoA Kinase from Aquifex aeolicus, Northeast Structural Genomics Target QR72.'''
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2if2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2if2 OCA], [https://pdbe.org/2if2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2if2 RCSB], [https://www.ebi.ac.uk/pdbsum/2if2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2if2 ProSAT], [https://www.topsan.org/Proteins/NESGC/2if2 TOPSAN]</span></td></tr>
 
</table>
 
== Function ==
==About this Structure==
[[https://www.uniprot.org/uniprot/COAE_AQUAE COAE_AQUAE]] Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity).  
2IF2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF2 OCA].  
== Evolutionary Conservation ==
[[Category: Aquifex aeolicus]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2if2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2if2 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Aquae]]
[[Category: Dephospho-CoA kinase]]
[[Category: Dephospho-CoA kinase]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Acton, T B.]]
[[Category: Acton, T B]]
[[Category: Baran, M.]]
[[Category: Baran, M]]
[[Category: Cunningham, K.]]
[[Category: Cunningham, K]]
[[Category: Fang, Y.]]
[[Category: Fang, Y]]
[[Category: Forouhar, F.]]
[[Category: Forouhar, F]]
[[Category: Hunt, J F.]]
[[Category: Hunt, J F]]
[[Category: Hussain, A.]]
[[Category: Hussain, A]]
[[Category: Hussain, M.]]
[[Category: Hussain, M]]
[[Category: Liu, J.]]
[[Category: Liu, J]]
[[Category: Ma, L C.]]
[[Category: Ma, L C]]
[[Category: Montelione, G T.]]
[[Category: Montelione, G T]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Rost, B.]]
[[Category: Rost, B]]
[[Category: Seetharaman, J.]]
[[Category: Seetharaman, J]]
[[Category: Tong, L.]]
[[Category: Tong, L]]
[[Category: Wu, M.]]
[[Category: Wu, M]]
[[Category: Xiao, R.]]
[[Category: Xiao, R]]
[[Category: EDO]]
[[Category: Alpha-beta protein]]
[[Category: SO4]]
[[Category: Nesg]]
[[Category: alpha-beta protein]]
[[Category: PSI, Protein structure initiative]]
[[Category: nesg]]
[[Category: Transferase]]
[[Category: northeast structural genomics consortium]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:28:44 2008''

Latest revision as of 14:14, 31 March 2021

Crystal Structure of the Putative Dephospho-CoA Kinase from Aquifex aeolicus, Northeast Structural Genomics Target QR72.Crystal Structure of the Putative Dephospho-CoA Kinase from Aquifex aeolicus, Northeast Structural Genomics Target QR72.

Structural highlights

2if2 is a 3 chain structure with sequence from Aquae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Gene:coaE (AQUAE)
Activity:Dephospho-CoA kinase, with EC number 2.7.1.24
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[COAE_AQUAE] Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2if2, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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