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| == Function == | | == Function == |
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| '''Arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.<ref>PMID:7476363</ref> | | '''Arsenate reductase''' or '''glutaredoxin arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.<ref>PMID:7476363</ref> |
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| == Relevance == | | == Relevance == |
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| == Structural highlights == | | == Structural highlights == |
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| The AsR active site contains a <scene name='54/547051/Cv/4'>catalytic Cys residue which forms a covalent thiolate-As V intermediate</scene>. <scene name='54/547051/Cv/3'>Entire active site</scene> (PDB entry [[1j9b]]).<ref>PMID:11709171</ref> | | The AsR active site contains a <scene name='54/547051/Cv/5'>catalytic Cys residue which forms a covalent thiolate-As V intermediate</scene>. <scene name='54/547051/Cv/6'>Entire active site</scene> (PDB entry [[1j9b]]).<ref>PMID:11709171</ref> |
| </StructureSection>
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| == 3D structures of arsenate reducatse== | | == 3D structures of arsenate reductase== |
| | [[Arsenate reductase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Arsenate reductase
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| **[[1jf8]], [[1ljl]] – SaAsR – ''Staphylococcus aureus'' <BR />
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| **[[1jfv]], [[1lk0]], [[1rxi]], [[2cd7]], [[2fxi]] – SaAsR (mutant) <BR />
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| **[[1jl3]] – BsAsR – ''Bacillus subtilis'' <BR />
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| **[[1z2d]], [[1z2e]] – BsAsR - NMR <BR />
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| **[[1i9d]] – EcAsR – ''Escherichia coli'' <BR />
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| **[[1s3c]], [[1s3d]], [[1sd8]], [[1sd9]], [[1sk2]] – EcAsR (mutant) <BR />
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| **[[2l17]], [[2l18]] – SyAsR – ''Synechocystis'' - NMR<BR />
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| **[[2l19]] – SyAsR (mutant) - NMR<BR />
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| **[[1y1l]] – AsR – ''Archaeoglobus fulgidus''<br />
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| **[[3f0i]] – AsR – ''Vibrio cholerae''<br />
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| **[[3rh0]], [[3t38]] – AsR – ''Corynebacterium glutamicum''<br />
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| *Arsenate reductase complexes
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| **[[1jzw]] – EcAsR + arsonocysteine <BR />
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| **[[1sk1]] – EcAsR (mutant) + arsonocysteine <BR />
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| **[[1sjz]], [[1sk0]] – EcAsR (mutant) + arsonocysteine + AsO3<BR />
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| **[[1j9b]] – EcAsR + AsO3 + thiarsahydroxy-cysteine<BR />
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| **[[1lju]] – SaAsR (mutant) + arsonocysteine <BR />
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| **[[1rxe]] – SaAsR (mutant) + mercapto-nitrobenzoate <BR />
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| **[[2ipa]] – BsAsR (mutant) + thioredoxin (mutant)<BR />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |