Arsenate reductase: Difference between revisions

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== Function ==
== Function ==


'''Arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.<ref>PMID:7476363</ref>   
'''Arsenate reductase''' or '''glutaredoxin arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.<ref>PMID:7476363</ref>   


== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==


The AsR active site contains a <scene name='54/547051/Cv/4'>catalytic Cys residue which forms a covalent thiolate-As V intermediate</scene>. <scene name='54/547051/Cv/3'>Entire active site</scene>.  
The AsR active site contains a <scene name='54/547051/Cv/5'>catalytic Cys residue which forms a covalent thiolate-As V intermediate</scene>. <scene name='54/547051/Cv/6'>Entire active site</scene> (PDB entry [[1j9b]]).<ref>PMID:11709171</ref>  
</StructureSection>


== 3D structures of arsenate reducatse==
== 3D structures of arsenate reductase==
[[Arsenate reductase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* Arsenate reductase
 
**[[1jf8]], [[1ljl]] – SaAsR – ''Staphylococcus aureus'' <BR />
**[[1jfv]], [[1lk0]], [[1rxi]], [[2cd7]], [[2fxi]] – SaAsR (mutant) <BR />
**[[1jl3]] – BsAsR – ''Bacillus subtilis'' <BR />
**[[1z2d]], [[1z2e]] – BsAsR - NMR <BR />
**[[1i9d]] – EcAsR – ''Escherichia coli'' <BR />
**[[1s3c]], [[1s3d]], [[1sd8]], [[1sd9]], [[1sk2]] – EcAsR (mutant) <BR />
**[[2l17]], [[2l18]] – SyAsR – ''Synechocystis'' - NMR<BR />
**[[2l19]] – SyAsR (mutant) - NMR<BR />
**[[1y1l]] – AsR – ''Archaeoglobus fulgidus''<br />
**[[3f0i]] – AsR – ''Vibrio cholerae''<br />
**[[3rh0]], [[3t38]] – AsR – ''Corynebacterium glutamicum''<br />
 
*Arsenate reductase complexes


**[[1jzw]] – EcAsR + arsonocysteine <BR />
**[[1sk1]] – EcAsR (mutant) + arsonocysteine <BR />
**[[1sjz]], [[1sk0]] – EcAsR (mutant) + arsonocysteine + AsO3<BR />
**[[1j9b]] – EcAsR + AsO3 + thiarsahydroxy-cysteine<BR />
**[[1lju]] – SaAsR (mutant) + arsonocysteine <BR />
**[[1rxe]] – SaAsR (mutant) + mercapto-nitrobenzoate <BR />
**[[2ipa]] – BsAsR (mutant) + thioredoxin (mutant)<BR />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky