Arsenate reductase: Difference between revisions

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<StructureSection load='1j9b' size='350' side='right' caption='Structure of arsenate reductase complex with arsenate, thiarsahydroxy-cysteine, sulfate and Cs+ ion (dark purple)  (PDB entry [[1j9b]])' scene=''>
<StructureSection load='1j9b' size='350' side='right' caption='Structure of arsenate reductase complex with arsenate, thiarsahydroxy-cysteine, sulfate and Cs+ ion (dark purple)  (PDB entry [[1j9b]])' scene='54/547051/Cv/1'>
    
    
== Function ==
== Function ==


'''Arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.   
'''Arsenate reductase''' or '''glutaredoxin arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.<ref>PMID:7476363</ref>  


== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==


The AsR active site contains a catalytic Sys residue which forms a covalent thiolate-As V intermediate.
The AsR active site contains a <scene name='54/547051/Cv/5'>catalytic Cys residue which forms a covalent thiolate-As V intermediate</scene>. <scene name='54/547051/Cv/6'>Entire active site</scene> (PDB entry [[1j9b]]).<ref>PMID:11709171</ref>  
</StructureSection>


== 3D structures of arsenate reducatse==
== 3D structures of arsenate reductase==
[[Arsenate reductase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* Arsenate reductase
 
**[[1jf8]], [[1ljl]] – SaAsR – ''Staphylococcus aureus'' <BR />
**[[1jfv]], [[1lk0]], [[1rxi]], [[2cd7]], [[2fxi]] – SaAsR (mutant) <BR />
**[[1jl3]] – BsAsR – ''Bacillus subtilis'' <BR />
**[[1z2d]], [[1z2e]] – BsAsR - NMR <BR />
**[[1i9d]] – EcAsR – ''Escherichia coli'' <BR />
**[[1s3c]], [[1s3d]], [[1sd8]], [[1sd9]], [[1sk2]] – EcAsR (mutant) <BR />
**[[2l17]], [[2l18]] – SyAsR – ''Synechocystis'' - NMR<BR />
**[[2l19]] – SyAsR (mutant) - NMR<BR />
**[[1y1l]] – AsR – ''Archaeoglobus fulgidus''<br />
**[[3f0i]] – AsR – ''Vibrio cholerae''<br />
**[[3rh0]], [[3t38]] – AsR – ''Corynebacterium glutamicum''<br />
 
*Arsenate reductase complexes


**[[1jzw]] – EcAsR + arsonocysteine <BR />
== References ==
**[[1sk1]] – EcAsR (mutant) + arsonocysteine <BR />
<references/>
**[[1sjz]], [[1sk0]] – EcAsR (mutant) + arsonocysteine + AsO3<BR />
**[[1j9b]] – EcAsR + AsO3 + thiarsahydroxy-cysteine<BR />
**[[1lju]] – SaAsR (mutant) + arsonocysteine <BR />
**[[1rxe]] – SaAsR (mutant) + mercapto-nitrobenzoate <BR />
**[[2ipa]] – BsAsR (mutant) + thioredoxin (mutant)<BR />
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky