Arsenate reductase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='1j9b' size='350' side='right' caption='Structure of arsenate reductase complex with arsenate, thiarsahydroxy-cysteine, sulfate and Cs+ ion (dark purple)  (PDB entry [[1j9b]])' scene=''>
+<StructureSection load='1j9b' size='350' side='right' caption='Structure of arsenate reductase complex with arsenate, thiarsahydroxy-cysteine, sulfate and Cs+ ion (dark purple)  (PDB entry [[1j9b]])' scene='54/547051/Cv/1'>
+== Function ==
-'''Arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As) and glutaredoxin to arsenite and glutaredoxin disulfide.  AsR is part of the arsenic detoxification pathway.
+'''Arsenate reductase''' or '''glutaredoxin arsenate reductase''' (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.<ref>PMID:7476363</ref>
-== 3D structures of arsenate reducatse==
+== Relevance ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+AsR is part of the arsenic detoxification pathway.
-[[1jf8]], [[1ljl]] – SaAsR – ''Staphylococcus aureus'' <BR />
+== Structural highlights ==
-[[1jfv]], [[1lk0]], [[1rxi]], [[2cd7]], [[2fxi]] – SaAsR (mutant) <BR />
-[[1jl3]] – BsAsR – ''Bacillus subtilis'' <BR />
-[[1z2d]], [[1z2e]] – BsAsR - NMR <BR />
-[[1i9d]] – EcAsR – ''Escherichia coli'' <BR />
-[[1s3c]], [[1s3d]], [[1sd8]], [[1sd9]], [[1sk2]] – EcAsR (mutant) <BR />
-[[2l17]], [[2l18]] – SyAsR – ''Synechocystis'' - NMR<BR />
-[[2l19]] – SyAsR (mutant) - NMR<BR />
-===Arsenate reductase complexes===
+The AsR active site contains a <scene name='54/547051/Cv/5'>catalytic Cys residue which forms a covalent thiolate-As V intermediate</scene>. <scene name='54/547051/Cv/6'>Entire active site</scene> (PDB entry [[1j9b]]).<ref>PMID:11709171</ref>
-[[1jzw]] – EcAsR + arsonocysteine <BR />
+== 3D structures of arsenate reductase==
-[[1sk1]] – EcAsR (mutant) + arsonocysteine <BR />
+[[Arsenate reductase 3D structures]]
-[[1sjz]], [[1sk0]] – EcAsR (mutant) + arsonocysteine + AsO3<BR />
-[[1j9b]] – EcAsR + AsO3 + thiarsahydroxy-cysteine<BR />
+</StructureSection>
-[[1lju]] – SaAsR (mutant) + arsonocysteine <BR />
-[[1rxe]] – SaAsR (mutant) + mercapto-nitrobenzoate <BR />
+== References ==
-[[2ipa]] – BsAsR (mutant) + thioredoxin (mutant)<BR />
+<references/>
 [[Category:Topic Page]]