Rossmann fold: Difference between revisions
Noted that the beta strands in Rossmann folds are generally all parallel. |
m Rossman fold moved to Rossmann fold over redirect: correct spelling |
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|DATE=July 29, 2014 | |||
|OLDID=1964746 | |||
|BAMBEDDOI=10.1002/bmb.20849 | |||
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Note: This entry on the Rossmann fold has been published in Biochem. Mol. Biol. Educ.<ref name="Hanukoglu-2015">PMID:25704928</ref>. Please cite it as Biochem. Mol. Biol. Educ. 43:206-209, 2015. | Note: This entry on the Rossmann fold has been published in Biochem. Mol. Biol. Educ.<ref name="Hanukoglu-2015">PMID:25704928</ref>. Please cite it as Biochem. Mol. Biol. Educ. 43:206-209, 2015. | ||
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The following scenes illustrate some aspects of the structure. | The following scenes illustrate some aspects of the structure. | ||
As noted above, the Rossmann fold is associated with a specific consensus sequence of Gly-x-Gly-x-x-Gly at the region of the tight loop between the first β-strand the α-helix. | |||
The first two scenes demonstrate the location of the first two conserved glycines. | |||
To rotate the molecule click and hold left mouse button. | To rotate the molecule click and hold left mouse button. | ||
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As seen in the example in Fig. 5, the direction of the strands are all parallel. This represents a general trend in Rossmann folds. However in some Rossmann folds there may be some strands in anti-parallel direction.<ref name="Hanukoglu-2015" /> | As seen in the example in Fig. 5, the direction of the strands are all parallel. This represents a general trend in Rossmann folds. However in some Rossmann folds there may be some strands in anti-parallel direction.<ref name="Hanukoglu-2015" /> | ||
As compared to the direction of the β-strands, the direction of the helical segments is generally anti-parallel to the β-strands (Fig. 5). | |||
In some Rossmann fold domains, the segments in between the β-strands may include a complex series of helical and coiled segments (for example see [[3bhi]]). | |||
==Evolutionary origin of the βαβ fold == | ==Evolutionary origin of the βαβ fold == | ||