Interleukin-12: Difference between revisions
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<StructureSection load='1F45' size='340' side='right' caption=' | <StructureSection load='1F45' size='340' side='right' caption='Glycosylated human interleukin-12 α chain (green) and β chain (grey) (PDB code [[1f45]]).' scene=''> | ||
== Background == | == Background == | ||
Interleukin-12 also known as IL-12, is produced by many different cells such as macrophages, B cells, and neutrophils. These cells produce IL-12 to generate immunity to pathogens. It can also stimulate the proliferation of natural killer cells, which are cells that can specifically target and kill cells that have been affected by pathogens. IL-12 is also a heterodimeric glycoprotein. This means that IL-12 has two subunits that are linked by a di-sulfide bond. That di-sulfide bond is not necessary for the formation of IL-12. It is also not necessary for the secretion of IL-12, but the di-sulfide bonds help to stabilize the subunits. There have been studies done to see its effects on immunotherapy. | '''Interleukin-12''' also known as '''IL-12''', is produced by many different cells such as macrophages, B cells, and neutrophils. These cells produce IL-12 to generate immunity to pathogens. It can also stimulate the proliferation of natural killer cells, which are cells that can specifically target and kill cells that have been affected by pathogens. IL-12 is also a heterodimeric glycoprotein. This means that IL-12 has two subunits that are linked by a di-sulfide bond. That di-sulfide bond is not necessary for the formation of IL-12. It is also not necessary for the secretion of IL-12, but the di-sulfide bonds help to stabilize the subunits. There have been studies done to see its effects on immunotherapy. | ||
== What it is == | == What it is == | ||