YbgF: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Laura McCauley, Michal Harel, Alexander Berchansky, Joel L. Sussman

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-[[Image:YbgF.jpg|300px|left|thumb| The Structure of YbgF<ref name='Gerding'>PMID: 17233825</ref>  ]]
+<StructureSection load='2xev' size='350' side='right' scene='' caption='YbgF TPR domain complex with Zn+2 (grey) and Ca+2 (green) ions (PDB code [[2xev]])'>
-{{STRUCTURE_2xev|  PDB=2xev  | SIZE=400| SCENE=YbgF/Ntermygbf/1 |right|CAPTION=Ybgf TPR domain, [[2xev]] }}
+[[Image:YbgF.jpg|200px|left|thumb| The Structure of YbgF<ref name='Gerding'>PMID: 17233825</ref>  ]]
-{{STRUCTURE_2wz7|  PDB=2wz7  | SIZE=400| SCENE=YbgF/Ybgf/1 |right|CAPTION=E. Coli Ybgf N terminal, [[2wz7]] }}
+{{Clear}}
+__TOC__
-{{STRUCTURE_2xev |  PDB=2xev  |  SCENE= YbgF/Ntermygbf/1 }}
-{{STRUCTURE_2wz7 |  PDB=2wz7  |  SCENE= YbgF/Ybgf/1 }}
 ==Structure==
-YbgF is a periplasmic protein with an N-terminal coiled coil domain (NTD) and a C-terminal tetratricopeptide domain (TPR), both of which are autonomous<ref name='Gerding'>PMID: 17233825</ref>.  As seen in the 3D structure 2WZ7, the NTD forms an elongated trimer which is connected via a flexible linker to the TPR trimer, as seen in 2XEV.  This connection can be cleaved by proteases<ref name='Krachler'>PMID: 20816983</ref>.
+'''YbgF''' is a periplasmic protein with an N-terminal coiled coil domain (NTD) and a C-terminal tetratricopeptide domain (TPR), both of which are autonomous<ref name='Gerding'>PMID: 17233825</ref>.  As seen in the <scene name='42/429024/Cv/1'>3D structure 2WZ7</scene>, the NTD forms an elongated trimer which is connected via a flexible linker to the TPR trimer, <scene name='42/429024/Cv/2'>as seen in 2XEV</scene>.  This connection can be cleaved by proteases<ref name='Krachler'>PMID: 20816983</ref>.
 ==Function==
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 Studies have shown that inactivation of the YbgF gene results in no discernible change in the activity of Tol<ref name='Walberger'>PMID: 11994151</ref>.  Therefore, replacing the protein with another would not rescue any lost function.  Future research may look into comparison of different gram negative bacteria in order to determine if the function is conserved.  One particular organism that is known to not have this domain conserved is ''Chlamydiae''<ref name='Krachler'>PMID: 20816983</ref>.  Future research may look into the functioning of its Tol system, with a the possible addition of the YbgF domain to study what effect this might have.
-==3D structures of Ygbf==
+==3D structures of Ybgf==
-[[2wz7]], [[2xdj]] – Ygbf N terminal – ''Escherichia coli''<br />
-[[2xev]] – Ygbf TPR domain – ''Xanthomonas campestris''
+[[2wz7]], [[2xdj]] – Ybgf N terminal – ''Escherichia coli''<br />
+[[2xev]] – Ybgf TPR domain – ''Xanthomonas campestris''
+</StructureSection>
 ==References==
 <references/>
+[[Category:Topic Page]]