Villin: Difference between revisions

[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the human supervillin headpiece, [[2k6n]]]]

{{STRUCTURE_2k6n| right| PDB=2k6n  |  SCENE=Villin/Cv/1 |CAPTION=Human supervillin headpiece, [[2k6n]] }}

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

[[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.  '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.  '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.  '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right  correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]).

 

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=== Supervillin ===

[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />

=== Villin ===

[[3fg7]] – hVIL gelsolin domains 4-6<br />

[[2llf]] - hVIL gelsolin-like domain 6 - NMR<br />

[[1unc]] – hVIL headpiece<br />

[[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br />

[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]] – cVIL headpiece (mutant) – chicken<br />

[[1yu5]], [[1qqv]] - cVIL headpiece<br />

[[3myc]], [[3mye]], [[3nkj]], [[3mya]], [[3tjw]], [[3trv]], [[3trw]], [[3try]] - cVIL headpiece (mutant)<br />

[[1vii]], [[2vik]], [[2vil]] - cVIL headpiece - NMR<br />

[[2ppz]], [[2jm0]] - VIL headpiece (mutant) – synthetic – NMR<br />

[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL fragment (mutant) – synthetic<br />

=== Advillin ===

[[1und]] – hAVIL headpiece<br />

===Cytovillin===

[[1ni2]] – hCVIL  N terminal<br />