Villin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman

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-[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]]
+<StructureSection load='' size='340' side='right' caption='Human supervillin headpiece, [[2k6n]]' scene='Villin/Cv/1' >
-{{STRUCTURE_2k6n| right| PDB=2k6n  |  SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}
+== Function ==
-[[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.   '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.  '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons. The images on the left and right  correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]).
+* [[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br />
+*   '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin<ref>PMID:20309963</ref>.<br />
+*  '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br />
+*  '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton<ref>PMID:8089177</ref>.
-<br />
+== Relevance ==
-{{TOC limit|limit=2}}
+VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID)<ref>PMID:25517957</ref>.
+</StructureSection>
+== 3D Structures of Villin ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+* Supervillin
-== 3D Structures of Villin ==
+**[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />
-''Update June 2011''
+* Villin
-<br />
-<br />
-<br />
-<br />
-<br />
-=== Supervillin ===
+**[[3fg7]] – hVIL-1 gelsolin domains 4-6<br />
+**[[1unc]] – hVIL-1 headpiece<br />
+**[[3iur]] - hVIL headpiece H2H3 helices + prolyl endopeptidase <br />
+**[[1yu5]], [[1qqv]] - cVIL headpiece - chicken<br />
+**[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]], [[3myc]], [[3mye]], [[3nkj]], [[3mya]], [[3tjw]], [[3trv]], [[3trw]], [[3try]] - cVIL-1 headpiece (mutant)<br />
+**[[2llf]] - cVIL-1 gelsolin-like domain 6 - NMR<br />
+**[[5i1n]], [[5i1o]], [[5i1p]], [[5i1s]] – cVIL-1 + cVIL headpiece<br />
+**[[1vii]], [[2vik]], [[2vil]], [[4cz3]], [[4cz4]] - cVIL-14T headpiece - NMR<br />
+**[[2ppz]], [[2jm0]] - VIL-1 headpiece (mutant) – synthetic – NMR<br />
+**[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL-1 fragment (mutant) – synthetic<br />
+**[[5vnt]] - VIL-4 C-terminal headpiece - ''Arabidopsis thaliana'' - NMR<br />
-[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />
+* Advillin
-=== Villin ===
+**[[1und]] – hAVIL headpiece<br />
-[[3fg7]] – hVIL gelsolin domains 4-6<br />
+*Cytovillin or ezrin
-[[1unc]] – hVIL headpiece<br />
-[[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br />
-[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]] – cVIL headpiece (mutant) – chicken<br />
-[[1yu5]], [[1qqv]] - cVIL headpiece<br />
-[[3myc]], [[3mye]], [[3nkj]] - cVIL headpiece (mutant)<br />
-[[1vii]], [[2vik]], [[2vil]] - cVIL headpiece - NMR<br />
-[[2ppz]], [[2jm0]] - VIL headpiece (mutant) – synthetic – NMR<br />
-[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL fragment (mutant) – synthetic<br />
-=== Advillin ===
+**[[1ni2]] – hCVIL  N terminal<br />
+**[[4rm8]], [[4rm9]] – hCVIL  <br />
+**[[4rma]] – hCVIL  FERM domain<br />
-[[1und]] – hAVIL headpiece<br />
+}}
 ==References==