Ectonucleotide pyrophosphatase/phosphodiesterase: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

@@ Line 7: / Line 7: @@
 *'''Ectonucleotide pyrophosphatase/phosphodiesterase 1''' (ENPP1) converts extracellular nucleotides into inorganic pyrophosphate<ref>PMID:23041369</ref>.  It regulates osteoblast differentiation<ref>PMID:21930712</ref><br />
-*'''Ectonucleotide pyrophosphatase/phosphodiesterase 2''' or '''autotoxin''' (ENPP2) hydrolyzes lysophospholipids<ref>PMID:23041369</ref><br />
+*'''Ectonucleotide pyrophosphatase/phosphodiesterase 2''' or '''autotaxin''' (ENPP2) hydrolyzes lysophospholipids<ref>PMID:23041369</ref><br />
 *'''Ectonucleotide pyrophosphatase/phosphodiesterase 4''' or (ENPP4) is an extracellular membrane protein which hydrolyzes adenine dinucleotide Ap3A thus causing platelet aggregation<ref>PMID:24338010</ref><br />
 *'''Ectonucleotide pyrophosphatase/phosphodiesterase 6''' (ENPP6) hydrolyzes choline-containing compounds like  lysophosphatidylcholine<ref>PMID:23161088</ref><br />
@@ Line 18: / Line 18: @@
 == Structural highlights ==
-The active site of ENPP1 contains <scene name='77/775922/Cv/3'>two functionally significant Zn+2 ions</scene> and the <scene name='77/775922/Cv/4'>reaction product AMP</scene><ref>PMID:23027977</ref>.
+The active site of ENPP1 contains <scene name='77/775922/Cv/5'>two functionally significant Zn+2 ions</scene> and the <scene name='77/775922/Cv/6'>reaction product AMP</scene><ref>PMID:23027977</ref>. <scene name='77/775922/Cv/7'>Surface representation of the AMP binding site</scene>.
 == 3D Structures of ectonucleotide pyrophosphatase/phosphodiesterase ==