Ectonucleotide pyrophosphatase/phosphodiesterase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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 <StructureSection load='4gtw' size='400' side='right' caption='Mouse glycosylated Se-Met ENPP1 complex with AMP and Ca+2 (green) and Zn+2 ions (grey) (PDB code [[4gtw]])' scene='77/775922/Cv/1'>
+__TOC__
 == Function ==
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 *'''Ectonucleotide pyrophosphatase/phosphodiesterase 1''' (ENPP1) converts extracellular nucleotides into inorganic pyrophosphate<ref>PMID:23041369</ref>.  It regulates osteoblast differentiation<ref>PMID:21930712</ref><br />
-*'''Ectonucleotide pyrophosphatase/phosphodiesterase 2''' or '''autotoxin''' (ENPP2) hydrolyzes lysophospholipids<ref>PMID:23041369</ref><br />
+*'''Ectonucleotide pyrophosphatase/phosphodiesterase 2''' or '''autotaxin''' (ENPP2) hydrolyzes lysophospholipids<ref>PMID:23041369</ref><br />
 *'''Ectonucleotide pyrophosphatase/phosphodiesterase 4''' or (ENPP4) is an extracellular membrane protein which hydrolyzes adenine dinucleotide Ap3A thus causing platelet aggregation<ref>PMID:24338010</ref><br />
 *'''Ectonucleotide pyrophosphatase/phosphodiesterase 6''' (ENPP6) hydrolyzes choline-containing compounds like  lysophosphatidylcholine<ref>PMID:23161088</ref><br />
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 == Structural highlights ==
-The active site of ENPP1 contains <scene name='77/775922/Cv/3'>two functionally significant Zn+2 ions</scene> and the <scene name='77/775922/Cv/4'>reaction product AMP</scene><ref>PMID:23027977</ref>.
+The active site of ENPP1 contains <scene name='77/775922/Cv/5'>two functionally significant Zn+2 ions</scene> and the <scene name='77/775922/Cv/6'>reaction product AMP</scene><ref>PMID:23027977</ref>. <scene name='77/775922/Cv/7'>Surface representation of the AMP binding site</scene>.
-</StructureSection>
 == 3D Structures of ectonucleotide pyrophosphatase/phosphodiesterase ==
+[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*ENPP1
-**[[4b56]] – mENPP1 – mouse <br />
-**[[2ys0]] – hENPP1 somatomedin domain – human - NMR <br />
-**[[4gtw]], [[4gtx]], [[4gty]], [[4gtz]] – mENPP1 (mutant) + nucleotide <br />
-*ENPP2 (Autotoxin)
-**[[5ijq]], [[5ijs]] – rENPP2 - rat<br />
-**[[2xr9]] – rENPP2 (mutant) <br />
-**[[5l0b]], [[5l0e]], [[5l0k]] – rENPP2 + inhibitor <br />
-**[[5lqq]], [[5m0d]], [[2xrg]], [[5m0e]], [[5m0m]], [[5m0s]] – rENPP2 (mutant) + inhibitor <br />
-**[[5dlt]], [[5dlw]], [[5dlv]] – rENPP2 (mutant) + steroid <br />
-**[[3nkm]], [[5inh]] – mENPP2 <br />
-**[[3nkn]], [[3nko]], [[3nkp]], [[3nkq]], [[3nkr]] – mENPP2 + lipid<br />
-**[[5hrt]] – mENPP2 + DNA<br />
-**[[3wav]], [[3waw]], [[3wax]], [[3way]], [[5lia]], [[5ohi]], [[5olb]] – mENPP2 + inhibitor<br />
-**[[4zg6]], [[4zg7]], [[4zg9]], [[4zga]], [[5kxa]], [[5m7m]], [[5mhp]] – hENPP2 (mutant) + inhibitor <br />
-*ENPP3
-**[[6c01]] – hENPP3 <br />
-**[[6c02]] – hENPP3 + AMPCPP <br />
-*ENPP4
-**[[4lr2]] – hENPP4 <br />
-**[[4lqy]] – hENPP4 + AMP <br />
-*ENPP5
-**[[5vem]], [[5ven]] – hENPP5  <br />
-**[[5veo]] – mENPP5 (mutant) + AMP <br />
-*ENPP6
-**[[5ege]] – mENPP6 (mutant) <br />
-**[[5egh]] – mENPP6 (mutant) + phosphocholine<br />
-*ENPP7 (Alkaline sphingomyelinase)
-**[[5udy]] – hENPP7 <br />
-**[[5tcd]] – hENPP7 + phosphocholine<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]