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Tryptophan RNA-binding attenuation protein: Difference between revisions

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<StructureSection load='2exs' size='340' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with RNA and Trp (PDB code [[1utf]]).' scene=''>
<StructureSection load='2exs' size='350' side='right' caption='Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code [[2exs]]).' scene=''>


== Function ==
== Function ==


'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes.  TRAP is composed of 11 identical subunits arranged in a symmetrical ring.  Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP.
'''Tryptophan RNA-binding attenuation protein''' (TRAP) or '''transcription attenuation protein MtrB''' is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes.  Down regulation of Trp biosynthesis is observed upon binding of 11 tryptophan molecules to TRAP<ref>PMID:14687568</ref>.
 
== Disease ==
 
== Relevance ==


== Structural highlights ==
== Structural highlights ==
TRAP is composed of 11 identical subunits arranged in a <scene name='59/595823/Cv/4'>symmetrical ring</scene>. The <scene name='59/595823/Cv/3'>active site of TRAP</scene><ref>PMID:16698553</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>


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**[[2zdo]], [[2exs]], [[2ext]], [[2zcz]], [[2zd0]], [[3zzs]], [[1qaw]] – GsTRAP + Trp<br />
**[[2zdo]], [[2exs]], [[2ext]], [[2zcz]], [[2zd0]], [[3zzs]], [[1qaw]] – GsTRAP + Trp<br />
**[[5eew]], [[5eex]], [[5eey]], [[5eez]], [[5ef0]], [[5ef1]], [[5ef2]], [[5ef3]]  – GsTRAP + Trp – radiation damage<br />
**[[1wap]], [[3zzq]] – BsTRAP + Trp – ''Bacillus subtilis''<br />
**[[1wap]], [[3zzq]] – BsTRAP + Trp – ''Bacillus subtilis''<br />
**[[4b27]] – BsTRAP (mutant) + Trp <br />
**[[4b27]] – BsTRAP (mutant) + Trp <br />
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*Tryptophan RNA-binding attenuation protein ternary complex with Trp
*Tryptophan RNA-binding attenuation protein ternary complex with Trp


**[[1c9s]], [[1gtf]], [[1gtn]], [[1utd]], [[1utf]], [[1utv]] – GsTRAP + RNA + Trp <br />
**[[1c9s]], [[1gtf]], [[1gtn]], [[1utd]], [[4v4f]] – GsTRAP + RNA + Trp <br />
**[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />
**[[2zp8]], [[2zp9]] – GsTRAP + TRAP inhibitory protein + Trp <br />


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Michal Harel, Alexander Berchansky
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