Tetherin: Difference between revisions
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<StructureSection load='2xg7' size='350' side='right' scene='' caption='Glycosylated human tetherin ectodomain dimer [[2xg7]]'> | |||
==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells== | ==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells== | ||
'''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. | '''Tetherin''' or '''bone marrow stromal antigen 2''' (BST-2) has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. | ||
The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. | The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. | ||
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*[[Viral Infections]] | *[[Viral Infections]] | ||
<br /> | <br /> | ||
</StructureSection> | |||
==3D structures of tetherin== | ==3D structures of tetherin== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[2x7a]], [[3nwh]], [[2xg7]], [[3mqb]] – | [[2x7a]], [[3nwh]], [[2xg7]], [[3mqb]], [[3mqc]] – hBST-2 ectodomain – human<br /> | ||
[[3mq7]] - | [[3mq7]], [[3mq9]] - hBST-2 ectodomain (mutant)<br /> | ||
[[2lk9]] – hBST-2 transmembrane (mutant) – NMR<br /> | |||
[[4p6z]] – hBST-2 in adaptor protein complex<br /> | |||
[[6cm9]], [[6owt]], [[6cri]], [[6d83]], [[6d84]], [[6dff]] – hBST-2/Nef in adaptor protein complex – Cryo EM<br /> | |||
[[3ni0]] - BST-2 ectodomain – mouse<br /> | |||