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Spermidine Synthase: Difference between revisions

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== Function ==
== Function ==
Polyamines are essential in all branches of life. '''Spermidine synthase''' (putrescine aminopropyltransferase, PAPT) (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine<ref>PMID:17585781</ref>.  SPS catalyzes the transfer of aminopropyl group from decarboxylated S-adenosylmethionine (SAM) to the amine acceptor spermidine.
Polyamines are essential in all branches of life. '''Spermidine synthase''' (or '''putrescine aminopropyltransferase, polyamine aminopropyltransferase, PAPT''') (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine<ref>PMID:17585781</ref>.  SPS catalyzes the transfer of aminopropyl group from decarboxylated S-adenosylmethionine (SAM) to the amine acceptor spermidine.  '''N4-Bis(aminopropyl) spermidine synthase''' or '''branched-chain polyamine synthase''' is an aminopropyltransferase essential for synthesis of branched-chain polyamines which enables thermophiles to grow in high temperature environments<ref>PMID:24610711</ref>.


== Disease ==
== Disease ==
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==Structural highlights ==
==Structural highlights ==
<scene name='49/497058/Cv/7'>SPS active site contains the substrate spermidine</scene><ref>PMID:18367445</ref>. Water molecules are shown as red spheres.
<scene name='49/497058/Cv/7'>SPS active site contains the substrate spermidine</scene><ref>PMID:18367445</ref>. Water molecules are shown as red spheres.
</StructureSection>
 
==3D structures of spermidine synthase==
==3D structures of spermidine synthase==
[[Spermidine synthase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Spermidine synthase
 
**[[1inl]] – TmSPS – ''Thermotoga maritima''<br />
**[[1mjf]] – SPS – ''Pyrococcus furiosus''<br />
**[[2e5w]], [[2zsu]] - SPS – ''Pyrococcus horikishii''<br />
**[[1iy9]] – SPS – ''Bacillus subtilis''<br />
**[[1xj5]], [[2q41]] – SPS – ''Arabidopsis thaliana''<br />
**[[2b2c]] – SPS – ''Caenorhabditis elegans''<br />
**[[2o05]], [[2o06]], [[2o07]], [[2o0l]] – SPS – human<br />
**[[2cmg]], [[2cmh]] – SPS – ''Helicobacter pylori''<br />
**[[2pss]] – PfSPS – ''Plasmodium falciparum''<br />
**[[3o4f]] – SPS – ''Escherichia coli''<br />
**[[3bwc]] - TcSPS – ''Trypanosoma cruzi''<br />
 
*Binary complexes of spermidine synthase
 
**[[1jq3]] – TmSPS + transition state analog<br />
**[[2hte]], [[2pt6]] - PfSPS + methylthioadenosine <br />
**[[2i7c]] - PfSPS + transition state analog<br />
**[[2pwp]] - PfSPS + spermidine<br />
**[[3b7p]] - PfSPS + spermine<br />
**[[3bwc]] - TcSPS + SAM <br />
**[[3rw9]] - hSPS + SAH<br />
**[[3anx]] – SPS + methylthioadenosine – ''Thermus thermophilus''<br />
 
*Ternary complexes of spermidine synthase
 
**[[3c6k]], [[4cxm]], [[4uoe]] - hSPS + methylthioadenosine + spermidine<br />
**[[3c6m]] - hSPS + methylthioadenosine + spermine<br />
**[[2pt6]], [[3rie]], [[4bp3]], [[4bp1]] - PfSPS + inhibitor + methylthioadenosine<br />
**[[2pt9]] - PfSPS + inhibitor + SAM derivative<br />
**[[4cwa]], [[5b1s]] - PfSPS + inhibitor + ethanol derivative<br />
**[[4yv0]], [[4yv1]], [[4yv2]], [[4yuv]], [[4yuw]], [[4yux]], [[4yuy]], [[4yuz]] - TcSPS + inhibitor + SAM derivative<br />


}}
== References ==
== References ==
<references/>
<references/>
Created with the participation of [[User:Lindsey Butler|Lindsey Butler]].   
Created with the participation of [[User:Lindsey Butler|Lindsey Butler]].   
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman
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