Proliferating Cell Nuclear Antigen: Difference between revisions
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] [[Proliferating Cell Nuclear Antigen]] (PCNA) is a protein that acts as a DNA sliding clamp. It forms a homotrimer encircling the DNA and binds other peptides means known as [[PCNA interacting proteins]]. It acts as a processivity factor for DNA polymerases and other enzymes which act upon DNA. Examples of such are DNA polymerase (Dpo) δ in eukaryotic cells<ref>PMID:26688547</ref>. The increases in processivity are very pronounced. The number of | [[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] [[Proliferating Cell Nuclear Antigen]] (PCNA) is a protein that acts as a DNA sliding clamp. It forms a homotrimer encircling the DNA and binds other peptides means known as [[PCNA interacting proteins]]. It acts as a processivity factor for DNA polymerases and other enzymes which act upon DNA. Examples of such are DNA polymerase (Dpo) δ in eukaryotic cells<ref>PMID:26688547</ref>. The increases in processivity are very pronounced. The number of base pairs processed before complex dissociation occurs is increased more than a thousandfold (~10bp<ref>PMID:7040370</ref> to ~80kbp<ref>PMID:19666586</ref>) and the speed of nucleotide incorporation rises about a hundredfold <ref>PMID:17707226</ref>. '''PCNA homolog''' is called '''DNA polymerase sliding clamp'''<ref>PMID:28267969</ref>. | ||
== Relevance == | == Relevance == | ||