Peroxiredoxin: Difference between revisions

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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-{{STRUCTURE_1qq2|  PDB=1qq2  | SIZE=400| SCENE= |right|CAPTION=Peroxiredoxin dimer complex with Cl- ions [[1qq2]]}}
+<StructureSection load='1qq2' size='350' side='right' scene='43/433646/Cv/2' caption='Typical 2-cys peroxiredoxin dimer complex with Cl- ions [[1qq2]]'>
+== Function ==
+[[Peroxiredoxin]] (Prx) is an antioxidant enzyme.  In the Prxs the active-site Cys is oxidized to sulfenic acid hyper oxide forming a Cys-SOH intermediate.  A second Cys residue resolves the intermediate to a protein disulfide bond.  The Prxs are divided into 3 types according to their intermediate resolving mechanism: '''typical 2-Cysteine Prx''' in which the Cys-Cys bond is formed between two subunits, '''atypical 2-Cys Prx''' in which the bond is formed within one subunit and '''1-Cysteine Prx''' which uses a single Cys residue for the catalysis. '''Prx Q''' is the plant homolog of [[Bacterioferritin comigratory protein]].
-[[Peroxiredoxin]] (Prx) is an antioxidant enzyme.  In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide.  The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue.
+'''Typical 2-Cys Prx'''<br />
+* '''Prx 1''' interacts with signaling molecules<ref>PMID:19923889</ref>.
+* '''Prx 2''' is essential for sustaining erythrocyte life span<ref>PMID:18479207</ref>.
+* '''Prx 3''' is mitochondria-specific.<ref>PMID:15280382</ref>.
+* '''Prx 4''' localizes to the cytoplasm and regulates the activation of NF-κB<ref>PMID:25656995</ref>.
+'''Atypical 2-Cys Prx'''<br />
+* '''Prx 5''' protects from mitochondrial DNA damage induced by H<sub>2</sub>O<sub>2</sub><ref>PMID:15848167</ref>.
+'''1-Cys Prx'''<br />
+* '''Prx 6''' reduces peroxidized membrane phospholipids<ref>PMID:20919932</ref>.
-== 3D Structures of Peroxiredoxin ==
+== Relevance ==
+Prx are over expressed in cancer tissue<ref>PMID:11497302</ref>.  Prx 4 mediates osteoclast activation in cancer cells<ref>PMID:25779674</ref>.
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== Structural highlights ==
-{{#tree:id=OrganizedByTopic|openlevels=0|
+In the typical 2-cysteine Prx the <scene name='43/433646/Cv/5'>Cys-Cys bond is formed between two subunits</scene><ref>PMID:10535922</ref>. <scene name='43/433646/Cv/6'>Cl coordination site</scene>. Water molecules is shown as red sphere.
-*Peroxiredoxin
+== 3D Structures of Peroxiredoxin ==
+[[Peroxiredoxin 3D structures]]
-**[[1qq2]] – r2Cys-Prx – rat<br />
-**[[2c0d]] – Pf2Cys-Prx – ''Plasmodium falciparum''<br />
-**[[1xiy]] – Pf1Cys-Prx<br />
-**[[1xcc]], [[2h01]], [[3tb2]] - 1Cys-Prx – ''Plasmodium yoelii''<br />
-**[[2i81]] - 2Cys-Prx – ''Plasmodium vivax''<br />
-**[[1qmv]] - h2Cys-Prx – human<br />
-**[[3cmi]] – yPrx hyr1 - yeast<br />
-**[[4g2e]] – Prx – ''Sulfolobus tokodaii''<br />
-**[[3sbc]] – yPrx Tsa1 (mutant)<br />
-**[[1uul]] - 2Cys-Prx – ''Trypanosoma cruzi''<br />
-**[[1we0]] – Prx – ''Amphibacillus xylanus''<br />
-**[[2cv4]], [[2cx3]], [[2cx4]] – Prx – ''Aeropyrum pernix''<br />
-**[[3drn]] – SsPrx – ''Sulfolobus solfataricus''<br />
-**[[3hjp]] – SsPrx (mutant)<br />
-**[[3ixr]] – Prx PRXQ (mutant) – ''Xylella fastidiosa''<br />
-*Peroxiredoxin 1
-**[[2rii]], [[3hy2]] – hPrx 1 (mutant)+sulfiredoxin 1<br />
-**[[2z9s]] – rPrx 1 (mutant) <br />
-**[[4kw6]], [[4fh8]] – Prx 1 – ''Ancylostoma ceylanicum''<br />
-**[[3zl5]] - mPrx 1 (mutant) – mouse<br />
-*Peroxiredoxin 2
-**[[1tp9]] – Prx  II – ''Populus trichocarpa''<br />
-**[[2pwj]] – Prx II – garden pea<br />
-**[[4dsq]], [[4dsr]], [[4h86]] – yPrx II<br />
-**[[4dss]] – yPrx II (mutant) + thioredoxin II<br />
-*Peroxiredoxin 3
-**[[1zye]] – Prx III (mutant) – bovine<br />
-*Peroxiredoxin 4
-**[[3tjf]], [[3tjg]], [[3tjj]], [[3tjk]], [[3tkr]] - hPrx 4 (mutant)<br />
-**[[3qpm]] – Prx 4 – ''Larimichtys crocea''<br />
-**[[2pn8]], [[3tjb]], [[3tkp]], [[3tkq]], [[3tks]]   – hPrx 4<br />
-**[[3vwu]], [[3vwv]] - mPrx 4 (mutant) <br />
-*Peroxiredoxin 5
-**[[1urm]] – hPrx 5 (mutant) – human<br />
-**[[2vl2]], [[2vl3]], [[2vl9]], [[1h4o]], [[1hd2]], [[1oc3]]  – hPrx 5<br />
-**[[3mng]] – hPrx 5+DTT<br />
-**[[2wfc]] – lPrx 5 - lugworm<br />
-**[[2xhf]] – Prx 5 – ''Alvinella pompejana''<br />
-*Peroxiredoxin 6
-**[[2v2g]] – lPrx 6 <br />
+</StructureSection>
-**[[2v32]], [[2v41]] – lPrx 6 (mutant)<br />
-}}
+== References ==
+<references/>
 [[Category:Topic Page]]